Ligands for E3 Ligase

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Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V83803	(S)-PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid
V83735	(S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc
V83726	(S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc
V85210	(S,R,S)-AHPC dihydrochloride (VH032-NH2 dihydrochloride; VHL ligand 1 dihydrochloride)	2137142-47-1
V4063	(S,R,S)-AHPC hydrochloride	1448189-80-7	Protein degrader 1 HCl (hydrochloride) or PROTAC-VHL-ligandis a novel and potent small molecule ligand forVHL (Von Hippel-Lindau), which is anE3 ligasewhich has been targeted in many PROTAC (proteolysis-targeting chimeras) degraders.
V83764	(S,R,S)-AHPC-acetyl-azetidine-PIP-boc
V83721	(S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc
V82564	(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH)	2086301-47-3	(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a ligand (for E3 ligase)-linker conjugate ( E3 ligase ligand-linker conjugate), containing VHL ligand.
V82555	(S,R,S)-AHPC-C10-NHBoc	2412055-13-9	(S,R,S)-AHPC-C10-NHBoc is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)-AHPC (HY -125845) VHL ligand and 1 linker.
V82542	(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3)	2597167-24-1	(S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)- AHPC's VHL ligand and 4-unit PEG linker. (S,R,S)-AHPC-C2-PEG4-N3 may be utilized in the synthesis/preparation of vRucaparib-TP4 .
V83795	(S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH
V83777	(S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc
V83759	(S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc
V2400	(S,R,S)-AHPC-Me	1948273-02-6	S,R,S)-AHPC-Me (also known as VHL ligand 2 or E3 ligase Ligand 1A) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
V82543	4-Boc-amino-2,2-dimethylbutyric acid	153039-17-9	4-Boc-amino-22-dimethylbutyric acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl/ether class, may be utilized to prepare PROTAC protein degraders.
V83736	4-Methylanisole-dihydrouracil-imidazo[1,2-a]pyridine-piperidine-NH-Boc
V82524	5-(Biotinamido)pentylazide	1349190-76-6	5-Biotinamidopentylazide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the alkyl chain class, may be utilized to prepare PROTAC molecules.
V82556	A 410099.1 amide-PEG2-amine-Boc	2415256-16-3	410099.1 amide-PEG2-amine-Boc is a functionalized IAP ligand for PROTAC, which combines an IAP ligand and an amide-PEG2 linker with an amide terminal to bind to the target protein ligand.
V82534	A 410099.1 amide-PEG3-amine-Boc	2415256-19-6	A 410099.1 amide-PEG3-amine-Boc is a functionalized IAP ligand for PROTAC, which combines an IAP ligand and an amide-PEG3 linker with an amide at the end, which can bind to the target protein ligand.
V82535	Acid-PEG2-ethyl propionate	886362-90-9	Acid-PEG2-ethyl propionate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.