A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.
E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V97355 | (3S)Lenalidomide-5-Br | 2829898-76-0 | (3S)Lenalidomide-5-Br is a ligand for E3 ubiquitinases. |
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V97123 | (S)-Deoxy-thalidomide | 107657-57-8 | (S)-Deoxythalidomide is an E3 ubiquitin ligase ligand. |
|
V83803 | (S)-PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid | ||
|
V83735 | (S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc | ||
|
V83726 | (S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc | ||
|
V100321 | (S,R,R)-VH032 | 2489876-59-5 | (S,R,R)-VH032 (compound V3) is a VHL ligand that can be used to synthesize PROTAC NCOA4 degrader-1. |
|
V85210 | (S,R,S)-AHPC dihydrochloride (VH032-NH2 dihydrochloride; VHL ligand 1 dihydrochloride) | 2137142-47-1 | |
|
V89049 | (S,R,S)-AHPC(Me)-amido-C2-acid | 2365173-01-7 | (S,R,S)-AHPC(Me)-amido-C2-acid is a VHL (E3 ligase) ligand that can be used to synthesize PROTACs, such as PROTAC STING Degrader-2. |
|
V97362 | (S,R,S)-AHPC-Ac | 2361116-63-2 | (S,R,S)-AHPC-Ac is a ligand for E3 ubiquitinases. |
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V83764 | (S,R,S)-AHPC-acetyl-azetidine-PIP-boc | ||
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V83721 | (S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc | ||
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V97267 | (S,R,S)-AHPC-Ala | 2641319-58-4 | (S,R,S)-AHPC-Ala is a ligand for E3 ubiquitinase. |
|
V82564 | (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) | 2086301-47-3 | (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a ligand (for E3 ligase)-linker conjugate ( E3 ligase ligand-linker conjugate), containing VHL ligand. |
|
V82555 | (S,R,S)-AHPC-C10-NHBoc | 2412055-13-9 | (S,R,S)-AHPC-C10-NHBoc is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)-AHPC (HY -125845) VHL ligand and 1 linker. |
|
V82542 | (S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) | 2597167-24-1 | (S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)- AHPC's VHL ligand and 4-unit PEG linker. (S,R,S)-AHPC-C2-PEG4-N3 may be utilized in the synthesis/preparation of vRucaparib-TP4 . |
|
V83795 | (S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH | ||
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V83777 | (S,R,S)-AHPC-CO-CH2-O-CH2-piperidine-Boc | ||
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V83759 | (S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc | ||
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V2400 | (S,R,S)-AHPC-Me | 1948273-02-6 | S,R,S)-AHPC-Me (also known as VHL ligand 2 or E3 ligase Ligand 1A) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. |
|
V97277 | (S,R,S)-AHPC-O-CF3 | 2641373-92-2 | (S,R,S)-AHPC-O-CF3 is a ligand for E3 ubiquitinase. |
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