A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.
E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V4063 | (S,R,S)-AHPC hydrochloride | 1448189-80-7 | Protein degrader 1 HCl (hydrochloride) or PROTAC-VHL-ligandis a novel and potent small molecule ligand forVHL (Von Hippel-Lindau), which is anE3 ligasewhich has been targeted in many PROTAC (proteolysis-targeting chimeras) degraders. | |
V82564 | (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) | 2086301-47-3 | (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a ligand (for E3 ligase)-linker conjugate ( E3 ligase ligand-linker conjugate), containing VHL ligand. | |
V82555 | (S,R,S)-AHPC-C10-NHBoc | 2412055-13-9 | (S,R,S)-AHPC-C10-NHBoc is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)-AHPC (HY -125845) VHL ligand and 1 linker. | |
V82542 | (S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) | 2597167-24-1 | (S,R,S)-AHPC-C2-PEG4-N3 (VH032-C2-PEG4-N3) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)- AHPC's VHL ligand and 4-unit PEG linker. (S,R,S)-AHPC-C2-PEG4-N3 may be utilized in the synthesis/preparation of vRucaparib-TP4 . | |
V2400 | (S,R,S)-AHPC-Me | 1948273-02-6 | S,R,S)-AHPC-Me (also known as VHL ligand 2 or E3 ligase Ligand 1A) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. | |
V82543 | 4-Boc-amino-2,2-dimethylbutyric acid | 153039-17-9 | 4-Boc-amino-22-dimethylbutyric acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl/ether class, may be utilized to prepare PROTAC protein degraders. | |
V82524 | 5-(Biotinamido)pentylazide | 1349190-76-6 | 5-Biotinamidopentylazide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the alkyl chain class, may be utilized to prepare PROTAC molecules. | |
V82556 | A 410099.1 amide-PEG2-amine-Boc | 2415256-16-3 | 410099.1 amide-PEG2-amine-Boc is a functionalized IAP ligand for PROTAC, which combines an IAP ligand and an amide-PEG2 linker with an amide terminal to bind to the target protein ligand. | |
V82534 | A 410099.1 amide-PEG3-amine-Boc | 2415256-19-6 | A 410099.1 amide-PEG3-amine-Boc is a functionalized IAP ligand for PROTAC, which combines an IAP ligand and an amide-PEG3 linker with an amide at the end, which can bind to the target protein ligand. | |
V82535 | Acid-PEG2-ethyl propionate | 886362-90-9 | Acid-PEG2-ethyl propionate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
V82570 | Acid-PEG25-NHSester | 2563872-17-1 | Acid-PEG25-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
V82573 | Acid-PEG7-t-butyl ester | 2134235-86-0 | Acid-PEG7-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class. | |
V82567 | Amino-PEG16-acid | 2922656-52-6 | Amino-PEG16-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. | |
V82599 | Azido-PEG10-Boc | 2490419-48-0 | Azido-PEG10-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules. | |
V82578 | Azido-PEG12-alcohol | 1111239-69-0 | Azido-PEG12-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. | |
V82538 | Azido-PEG3-chloroacetamide | 604766-23-6 | Azido-PEG3-chloroacetamide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. | |
V82550 | Azido-PEG3-MS | 176520-24-4 | Azido-PEG3-MS is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. | |
V82581 | Azido-PEG7-t-butyl ester | 2596867-40-0 | Azido-PEG7-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. | |
V82566 | Azido-PEG9-S-methyl ethanethioate | 2148986-33-6 | Azido-PEG9-S-methyl ethanethioate is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. | |
V82565 | Benzyl-PEG24-alcohol | 2218463-19-3 | Benzyl-PEG24-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |