Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation.E3 Ligase Binder, Linker, and Target Binder are the components of PROTACs. The Target Binder is a ligand (often a small-molecule inhibitor) for the protein of interest. When the PROTACs attach to the target protein, they can recruit E3 for target protein ubiquitination, which results in proteasome-mediated destruction of the protein. Because of this, PROTACs work by destroying the target proteins rather than blocking them, which is far more effective at overcoming resistance brought on by target mutation or overexpression. In order to overcome resistance, PROTAC technology has been used on a number of targets, including AR, ER, BTK, BET, and BCR-ABL.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V74715 | (4S)-PROTAC SOS1 degrader-1 | 2913176-81-3 | (4S)-PROTAC SOS1 degrader-1 is a potent PROTAC SOS1 degrader. |
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V83028 | (R,S,S)-VH032 | 2230826-33-0 | (R,S,S)-VH032 is Ligand for E3 Ligase used in the synthesis/preparation of PROTACs. |
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V83033 | (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA | 2417370-89-7 | (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-Me-C10-NH2 TFA is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)-AHPC ligand body and may be utilized in PROTAC studies. |
|
V83039 | (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA | 2417370-48-8 | (S,R,S)-AHPC-3-methylbutanyl acetate-methanesulfonothioate-PEG3-NH2 TFA is a ligand (for E3 ligase )-linker conjugate containing (S,R,S)-AHPC-based ligands. |
|
V83027 | (S,R,S)-AHPC-Me-C7 ester | 2639528-48-4 | (S,R,S)-AHPC-Me-C7 ester is an E3 ligase-connexin conjugate used in the preparation /synthesis of BCL-XL PROTAC protein degrader. |
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V67622 | A031 | 2682255-44-1 | A031 is a highly efficient PROTAC androgen receptor (AR) degrader that degrades AR protein with IC50 of less than 0.25 μM. |
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V37523 | ACBI1 | ACBI1 is a novel and potent PROTAC-based degrader of BAF ATPase subunits SMARCA2 and SMARCA4, it also degrades the polybromo-associated BAF (PBAF) complex member PBRM1 | |
|
V41715 | ACBI1 | 2375564-55-7 | ACBI1 (ACBI-1) is PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4 (DC50 = 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells) with anticancer activity. |
|
V58319 | AD4 | 2918262-09-4 | AD4 is an artemisinin analogue that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. |
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V67608 | ARD-2051 | 2632305-17-8 | ARD-2051 is a potent, orally bioactive, proteolytically targeted chimeric degrader of the androgen receptor (AR). |
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V67602 | ARD-2128 | 2222111-87-5 | ARD-2128 is a potent PROTAC androgen receptor (AR) degrader. |
|
V67594 | ARD-2585 | 2757422-79-8 | ARD-2585 is a potent, orally bioactive androgen receptor PROTAC protein degrader. |
|
V67601 | ARD-266 | 2666951-70-6 | ARD-266 is a highly efficient von Hippel-Lindau E3 ligase-based androgen receptor (AR) PROTAC degrader. |
|
V3579 | ARV-771 | 1949837-12-0 | ARV-771 (ARV771) is a novel and potent PROTAC-based degrader of bromodomain and extra-terminal (BET) proteins with the potential to be usedin the treatment of cancers such as CRPC. |
|
V3582 | AT6 | 2098836-50-9 | AT6 is a novel, potent and highly selective PROTAC-based BRD degrader, it isanalog of AT1. |
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V83051 | Biotin alkyne | 773888-45-2 | Biotin alkyne is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. |
|
V83031 | Boc-NH-PEG7-acetic acid | 141282-29-3 | Boc-NH-PEG7-acetic acid is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders. |
|
V3581 | BRD4 degrader AT1 | 2098836-45-2 | BRD4 degrader AT1 is a novel, potent and highly selectivePROTAC-based BRD4degrader (Kd= 44 nM for Brd4BD2in cells) with anticancer activity. |
|
V3439 | BSJ-03-123 | 2361493-16-3 | BSJ-03-123 is a novel, potentcyclin-dependent kinase 6 (CDK6)-selective small-molecule degrader (PROTAC: proteolysis targeting chimera). |
|
V77183 | BSJ-03-204triTFA | BSJ-03-204 triTFA is a PROTAC linked by Cereblon ligand and CDK ligand. |
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