Ligands for Target Protein for PROTAC

Target proteins are often proteins that may contribute significantly to the development of illnesses through overexpression or accumulation. Numerous PROTACs have been created to destroy kinases (like MEK, KRAS, CDK, and Bcr/Abl), transcription factors (like p53, STAT, RAR, ER, and AR), epigenetic tools (like HDAC and BET bromodomain), and E3 ligases themselves (like MDM2).

Target proteins are often proteins that may contribute significantly to the progression of illnesses through overexpression or accumulation. Numerous PROTACs have been created to destroy E3 ligases including MDM2, MEK, KRAS, CDK, and Bcr/Abl, transcription factors like p53, STAT, RAR, ER, and AR, epigenetic tools like HDAC, and BET bromodomain.

Ligands for Target Protein for PROTAC related products

Structure Cat No. Product Name CAS No. Product Description
V77307 Abemaciclib metabolite M18-d8 (LSN3106729-d8)
V82617 Amine-PEG3-Desthiobiotin 2237234-71-6
V82612 Amino-PEG23-amine 2673284-93-8
V82604 Azido-PEG8-TFP ester 1818294-49-3
V82609 Benzyl-PEG4-MS 477781-69-4
V82606 Benzyl-PEG5-Ots 129086-10-8
V82610 Bromo-PEG2-MS 1935075-34-5
V51058 CFT-1946 PROTAC BRAFV600X degrader
V31695 Dasatinib carbaldehyde 2112837-79-1 Dasatinib carbaldehyde, an analog of Dasatinib (BMS-354825;Sprycel) whichis an approved anticancer drug, binds to IAP ligand via a linker to form SNIPER .
V82605 DBCO-NHCO-PEG12-biotin 2621391-31-7
V51749 Dimethyl-F-OICR-9429-COOH 2407458-49-3 WDR5 ligand for PROTAC synthesis
V82613 Dimethylamino-PEG3 2741-30-2
V2592 DUPA 302941-52-2 DUPA belongs to a class of glutamate ureas.
V82614 Ethyl-PEG4-alcohol 5650-20-4
V79579 GID4 Ligand 1
V80174 GID4 Ligand 2
V82603 I-PEG6-OH 136399-07-0
V82611 Mal-PFP ester 138194-55-5
V82601 MS-PEG3-THP 357204-84-3
V82608 NH2-C2-NH-Boc-d4 (PROTAC Linker 22-d4) 509148-73-6
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