Ligands for Target Protein for PROTAC

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Ligands for Target Protein for PROTAC

Target proteins are often proteins that may contribute significantly to the development of illnesses through overexpression or accumulation. Numerous PROTACs have been created to destroy kinases (like MEK, KRAS, CDK, and Bcr/Abl), transcription factors (like p53, STAT, RAR, ER, and AR), epigenetic tools (like HDAC and BET bromodomain), and E3 ligases themselves (like MDM2).

Target proteins are often proteins that may contribute significantly to the progression of illnesses through overexpression or accumulation. Numerous PROTACs have been created to destroy E3 ligases including MDM2, MEK, KRAS, CDK, and Bcr/Abl, transcription factors like p53, STAT, RAR, ER, and AR, epigenetic tools like HDAC, and BET bromodomain.

Ligands for Target Protein for PROTAC related products

Cat No.	Product Name	CAS No.	Product Description
V84444	7α,25-Dihydroxycholesterol intermediate-1	1326612-12-7
V77307	Abemaciclib metabolite M18-d8 (LSN3106729-d8)		Abemaciclib metabolite M18-d8 is the deuterium labelled form of Abemaciclib metabolite M18.
V82617	Amine-PEG3-Desthiobiotin	2237234-71-6	Amine-PEG3-Desthiobiotin is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82612	Amino-PEG23-amine	2673284-93-8	Amino-PEG23-amine is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82604	Azido-PEG8-TFP ester	1818294-49-3	Azido-PEG8-TFP ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V86189	BCN-sulfonamide-PEG2-sulfonamide-N-bis(ethanol)	2126749-81-1
V82609	Benzyl-PEG4-MS	477781-69-4	Benzyl-PEG4-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82606	Benzyl-PEG5-Ots	129086-10-8	Benzyl-PEG8-Ots is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category.
V82610	Bromo-PEG2-MS	1935075-34-5	Bromo-PEG2-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V51058	CFT-1946		PROTAC BRAFV600X degrader
V31695	Dasatinib carbaldehyde	2112837-79-1	Dasatinib carbaldehyde, an analog of Dasatinib (BMS-354825;Sprycel) whichis an approved anticancer drug, binds to IAP ligand via a linker to form SNIPER .
V82605	DBCO-NHCO-PEG12-biotin	2621391-31-7	DBCO-NHCO-PEG12-biotin is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V51749	Dimethyl-F-OICR-9429-COOH	2407458-49-3	Dimethyl-F-OICR-9429-COOH is a ligand for the target protein WD40 repeat domain protein 5 (WDR5) and can be used for the synthesis of PROTAC.
V82613	Dimethylamino-PEG3	2741-30-2	Dimethylamino-PEG3 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V2592	DUPA	302941-52-2	DUPA is a glutamate urea that serves as a targeting moiety in a bioactive molecule conjugate for the selective and targeted delivery of cytotoxic drugs to prostate cancer/tumor cells.
V82614	Ethyl-PEG4-alcohol	5650-20-4	Ethyl-PEG4-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V79579	GID4 Ligand 1		GID4 Ligand 1 (Compound 88) is a cell-permeable (penetrable) and selective GID4 binder (IC50=5.4 μM; Kd=5.6 μM) that binds to GID4 in cells (EC50=558 nM).
V80174	GID4 Ligand 2		GID4 Ligand 2 (Compound 67) is a selective GID4M binder (IC50=18.9 μM; Kd=17 μM).
V82603	I-PEG6-OH	136399-07-0	I-PEG6-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82611	Mal-PFP ester	138194-55-5	Mal-PFP ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl/ether class, may be utilized to prepare PROTAC protein degraders.