Target proteins are often proteins that may contribute significantly to the development of illnesses through overexpression or accumulation. Numerous PROTACs have been created to destroy kinases (like MEK, KRAS, CDK, and Bcr/Abl), transcription factors (like p53, STAT, RAR, ER, and AR), epigenetic tools (like HDAC and BET bromodomain), and E3 ligases themselves (like MDM2).
Target proteins are often proteins that may contribute significantly to the progression of illnesses through overexpression or accumulation. Numerous PROTACs have been created to destroy E3 ligases including MDM2, MEK, KRAS, CDK, and Bcr/Abl, transcription factors like p53, STAT, RAR, ER, and AR, epigenetic tools like HDAC, and BET bromodomain.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V84444 | 7α,25-Dihydroxycholesterol intermediate-1 | 1326612-12-7 | |
|
V77307 | Abemaciclib metabolite M18-d8 (LSN3106729-d8) | Abemaciclib metabolite M18-d8 is the deuterium labelled form of Abemaciclib metabolite M18. | |
|
V87939 | Aberrant tau ligand 1 | 1892461-96-9 | Aberrant tau ligand 1 is a ligand for abnormal tau protein. |
|
V87279 | AKR1C3-IN-13 | AKR1C3-IN-13 (Compound 4) is an AKR1C3 inhibitor. | |
|
V82617 | Amine-PEG3-Desthiobiotin | 2237234-71-6 | Amine-PEG3-Desthiobiotin is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82612 | Amino-PEG23-amine | 2673284-93-8 | Amino-PEG23-amine is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82604 | Azido-PEG8-TFP ester | 1818294-49-3 | Azido-PEG8-TFP ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. |
|
V86189 | BCN-sulfonamide-PEG2-sulfonamide-N-bis(ethanol) | 2126749-81-1 | |
|
V82609 | Benzyl-PEG4-MS | 477781-69-4 | Benzyl-PEG4-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82606 | Benzyl-PEG5-Ots | 129086-10-8 | Benzyl-PEG8-Ots is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category. |
|
V82610 | Bromo-PEG2-MS | 1935075-34-5 | Bromo-PEG2-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V87944 | CBP/p300 ligand 4 | CBP/p300 ligand 4 (Compound 4) is an orally available CBP/p300 bromodomain inhibitor with IC50 of 91.4 nM. | |
|
V87946 | CBP/p300 ligand 5 | CBP/p300 ligand 5 is the target protein ligand of XYD129. | |
|
V87953 | CDK7 ligand 1 | CDK7 ligand 1 is an active control ligand for CDK7 ligand 2. | |
|
V87952 | CDK7 ligand 2 | 2603381-71-9 | CDK7 ligand 2 (Compound A6) is a CDK7 ligand. |
|
V51058 | CFT-1946 | PROTAC BRAFV600X degrader | |
|
V87942 | CYP1B1 ligand 2 | 2836297-58-4 | CYP1B1 ligand 2 is the target protein ligand of PROTAC CYP1B1 degrader-2. |
|
V82605 | DBCO-NHCO-PEG12-biotin | 2621391-31-7 | DBCO-NHCO-PEG12-biotin is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. |
|
V88229 | DENV ligand 1 | 1628758-48-4 | DENV ligand 1 is a ligand for DENV E protein. |
|
V88228 | DENV ligand 2 | DENV ligand 2 is a ligand for DENV E protein. |
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