Autophagosome-tethering compound (ATTEC) degrades target proteins via lysosomal pathway rather than common proteasome pathway. With a lower molecular weight than AUTAC, ATTEC breaks down target proteins through a molecular glue method. In order to move the target protein into the lysosome for breakdown, ATTEC first reduced the distance between the LC3 receptor and the target protein.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V131300 | CDK9 autophagic degrader 1 | 3066836-42-5 | CDK9 autophagic degrader 1 is an ATTEC degrader that can degrade CDK9 and affect the level of the related cell cycle protein T1. |
|
V2232 | LC3-mHTT-IN-AN1 | 486443-73-6 | LC3-mHTT-IN-AN1 (Compound AN1) is a novel mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. |
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