Autophagosome-tethering compound (ATTEC) degrades target proteins via lysosomal pathway rather than common proteasome pathway. With a lower molecular weight than AUTAC, ATTEC breaks down target proteins through a molecular glue method. In order to move the target protein into the lysosome for breakdown, ATTEC first reduced the distance between the LC3 receptor and the target protein.

ATTECs related products

Structure Cat No. Product Name CAS No. Product Description
V2232 LC3-mHTT-IN-AN1 486443-73-6 LC3-mHTT-IN-AN1 (Compound AN1) is a novel mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins.
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