LYTACs

Instead of the usual proteasome pathway, target proteins are destroyed by the lysosomal targeting chimera (LYTAC). By attaching to the lysosomal asialoglycoprotein receptor with its ligand, LYTAC breaks down its target proteins. LYTAC often has an antibody attached to the other side so that it may connect to the target protein and degrade it.

LYTACs related products

Cat No.	Product Name	CAS No.	Product Description
V87955	Biotin-εNle-CKCKC-γAbu-CKCKCG-NH2 (Cys modified with M6Pn)	3030990-42-9	Biotin-εNle-CKCKC-γAbu-CKCKCG-NH2 (Cys modified with M6Pn) (Compound 24) is a mannose-6-phosphate (M6Pn)-peptide conjugate that can be linked to targeting ligands of various proteins and successfully internalize and degrade these proteins via M6PR.
V82619	Chloroacetamido-C-PEG3-C3-NHBoc	934164-55-3	Chloroacetamido-C-PEG3-C3-NHBoc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V103419	GalNac-L96 analog	1159408-72-6	GalNac-L96 analogs are intermediates in the synthesis of the asialoglycoprotein receptor (ASGPR) ligand GalNAc-L96.
V82618	Thalidomide-5-O-CH2-COO(t-Bu)	2682112-10-1	Thalidomide-5-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide , which could be utilized as Cereblon ligand to recruit CRBN protein.
V51380	tri-GalNAc biotin		tri-GalNAc biotin is a small lysosomal molecule that targets degradants.
V51381	Tri-GalNAc(OAc)3	1159408-64-6	Tri-GalNAc(OAc)3 is a tri-GalNAc ligand that may be utilized to prepare GalNAc-LYTAC.
V51382	Tri-GalNAc(OAc)3 TFA	1159408-65-7	Tri-GalNAc(OAc)3 TFA is a tri-GalNAc ligand that may be utilized to prepare GalNAc-LYTAC.
V76397	Tri-GalNAc(OAc)3-Perfluorophenyl		Tri-GalNAc(OAc)3-Perfluorophenyl is pentafluorophenyl-modified Tri-GalNAc(OAc)3, a tri-GalNAc ligand that may be utilized to prepare GalNAc-LYTAC.
V51383	tri-GalNAc-COOH (acetylation)	3008204-26-7	tri-GalNAc-COOH acetylation is the acetylated and modified form of tri-GalNAc-COOH.
V51384	Tri-GalNAc-NHS ester	1953146-83-2	Tri-GalNAc-NHS ester is a lysosome targeting chimera (LYTAC) and a ligand for asialoglycoprotein receptor (ASGPR).