Instead of the usual proteasome pathway, target proteins are destroyed by the lysosomal targeting chimera (LYTAC). By attaching to the lysosomal asialoglycoprotein receptor with its ligand, LYTAC breaks down its target proteins. LYTAC often has an antibody attached to the other side so that it may connect to the target protein and degrade it.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V82619 | Chloroacetamido-C-PEG3-C3-NHBoc | 934164-55-3 | Chloroacetamido-C-PEG3-C3-NHBoc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V82618 | Thalidomide-5-O-CH2-COO(t-Bu) | 2682112-10-1 | Thalidomide-5-O-CH2-COO(t-Bu) is a t-Bu modified Thalidomide , which could be utilized as Cereblon ligand to recruit CRBN protein. |
|
V51380 | tri-GalNAc biotin | tri-GalNAc biotin is a small lysosomal molecule that targets degradants. | |
|
V51381 | Tri-GalNAc(OAc)3 | 1159408-64-6 | Tri-GalNAc(OAc)3 is a tri-GalNAc ligand that may be utilized to prepare GalNAc-LYTAC. |
|
V51382 | Tri-GalNAc(OAc)3 TFA | 1159408-65-7 | Tri-GalNAc(OAc)3 TFA is a tri-GalNAc ligand that may be utilized to prepare GalNAc-LYTAC. |
|
V76397 | Tri-GalNAc(OAc)3-Perfluorophenyl | Tri-GalNAc(OAc)3-Perfluorophenyl is pentafluorophenyl-modified Tri-GalNAc(OAc)3, a tri-GalNAc ligand that may be utilized to prepare GalNAc-LYTAC. | |
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V51383 | tri-GalNAc-COOH (acetylation) | tri-GalNAc-COOH acetylation is the acetylated and modified form of tri-GalNAc-COOH. | |
|
V51384 | Tri-GalNAc-NHS ester | 1953146-83-2 | Tri-GalNAc-NHS ester is a lysosome targeting chimera (LYTAC) and a ligand for asialoglycoprotein receptor (ASGPR). |
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