Ligands for E3 Ligase

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Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V78578	Thalidomide-NH-PEG6-NH2 hydrochloride		Thalidomide-NH-PEG6-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V82558	Thalidomide-O-C6-NHBoc	2509093-23-4	Thalidomide-O-C6-NHBoc is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V82526	Thalidomide-O-PEG4-amine TFA	2934561-88-1	Thalidomide-O-PEG4-amine TFA is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V79920	Thalidomide-PEG3-NH2 hydrochloride		Thalidomide-PEG3-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V82545	Thiol-C9-PEG4	130727-41-2	Thiol-C9-PEG4 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82521	Thiol-PEG2-t-butyl ester	1398044-50-2	Thiol-PEG2-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82539	Thiol-PEG3-acetic acid	200291-35-6	Thiol-PEG3-acetic acid is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V82527	THP-PEG10-OH	42607-90-9	THP-PEG10-OH is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the PEG category, may be utilized to prepare PROTAC protein degraders.
V82590	THP-PEG9-THP	1809333-14-9	THP-PEG9-THP is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the PEG category, may be utilized to prepare PROTAC protein degraders.
V82560	Triethylene glycol monodecyl ether	4669-23-2	Triethylene glycol monodecyl ether is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the PEG (Polyethylene glycol) class and may be utilized to prepare PROTAC molecules.
V4064	VH-298	2097381-85-4	VH-298 is a novel and highly potent inhibitor of theVHL:HIF-αprotein-protein interaction with aKdvalue of 80 to 90 nM, and has been used inPROTACtechnology.
V78462	VHL-IN-1		VHL-IN-1 (compound 30) is an inhibitor (blocker/antagonist) of ubiquitin E3 ligase von Hippel-Lindau (VHL) (dissociation constant Kd=37 nM), which stabilizes and induces HIF-1α transcriptional activity.
V51690	β-Naphthoflavone-CH2-OH (β-NF-CH2-OH)	2752755-32-9	β-Naphthoflavone-CH2-OH (β-NF-CH2-OH) is a ligand for the aryl hydrocarbon receptor (AhR) E3 ligase.