E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Structure Cat No. Product Name CAS No. Product Description
V82449 (S,R,S)-AHPC-C1-NH2 hydrochloride 2361120-26-3 (S,R,S)-AHPC-C1-NH2 HCl is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing a VHL complex based on (S,R,S)-AHPC. body and 1 linker, which may be utilized to prepare PROTAC molecules.
V82415 (S,R,S)-AHPC-C2-PEG3-BCN 2876198-36-4 (S,R,S)-AHPC-C2-PEG3-BCN (Compound 16b) is a VHL ligand that may be utilized in the preparation /synthesis of PROTACs
V84667 (S,R,S)-AHPC-C3-COOH 2172819-73-5
V82406 (S,R,S)-AHPC-C3-NH2 dihydrochloride (VH032-C3-NH2 dihydrochloride) 2564467-25-8 (S,R,S)-AHPC-C3-NH2 (di-HCl) is the di-HCl salt form of (S,R,S)-AHPC-C3-NH2 .
V82491 (S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) 2170695-19-7 (S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing the VHL ligand based on VH032 body and 1 linker.
V84649 (S,R,S)-AHPC-C5-NH2 dihydrochloride (VH032-C5-NH2 dihydrochloride) 2415256-20-9
V84528 (S,R,S)-AHPC-C7-amine dihydrochloride (VH032-C7-amine dihydrochloride) 2415256-17-4
V86270 (S,R,S)-AHPC-C7-amine hydrochloride (VH032-C7-amine hydrochloride) 2502189-41-3
V82344 (S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride; E3 ligase Ligand 1 dihydrochloride) 2504950-56-3 (S,R,S)-AHPC-Me di-HCl (VHL ligand 2 di-HCl) is a VHL ligand based on (S,R,S)-AHPC that recruits von Hippel-Lindau (VHL) protein.
V77947 (S,R,S)-AHPC-PEG1-OTs (VH032-PEG1-OTs; VHL Ligand-Linker Conjugates 2; E3 ligase Ligand-Linker Conjugates 51) (S,R,S)-AHPC-PEG1-OTs is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)-AHPC-based VHL ligand and 1 unit PEG linker .
V84609 (S,R,S)-AHPC-PEG3-NH2 dihydrochloride (VH032-PEG3-NH2 dihydrochloride; VHL Ligand-Linker Conjugates 1 dihydrochloride; E3 ligase Ligand-Linker Conjugates 5 dihydrochloride) 2376990-24-6
V84737 (S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid) 2172819-72-4
V82360 (−)-N-Hydroxyapiosporamide (NHAP) 1205676-02-3 (−)-N-Hydroxyapiosporamide (NHAP) is an alkaloid and an NF-κB inhibitor (antagonist) with potent anticancer effect in vitro and in vivo.
V82422 A 410099.1,amine-Boc 1613552-03-6 A 410099.1, amine-Boc is an IAP ligand that may be utilized in the synthesis/preparation of PROTACs, such as PROTACs against BTK (PROTACs 4 and 5).
V82385 Acid-PEG8-SS-PEG8-acid 873013-93-5 Acid-PEG8-SS-PEG8-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V51687 AhR Ligand-Linker Conjugates 1 2380012-98-4 AhR Ligand-Linker Conjugates 1 (E3 Ligase Ligand-Linker Conjugates 57) contain IAP ligands and linkers for recruiting E3 ubiquitin ligases.
V82339 Alkaline phosphatase (alkaline phosphatase; Apase) 9001-78-9 Alkaline phosphatase (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH.
V82346 ALV2 2438124-95-7 ALV2 is a potent and specific Helios degrader.
V82411 Amine-PEG4-Desthiobiotin 2306109-91-9 Amine-PEG4-Desthiobiotin is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82368 Amino-PEG11-acid 1616426-12-0 Amino-PEG11-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category.
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