E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Cat No.	Product Name	CAS No.	Product Description
V82449	(S,R,S)-AHPC-C1-NH2 hydrochloride	2361120-26-3	(S,R,S)-AHPC-C1-NH2 HCl is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing a VHL complex based on (S,R,S)-AHPC. body and 1 linker, which may be utilized to prepare PROTAC molecules.
V82415	(S,R,S)-AHPC-C2-PEG3-BCN	2876198-36-4	(S,R,S)-AHPC-C2-PEG3-BCN (Compound 16b) is a VHL ligand that may be utilized in the preparation /synthesis of PROTACs
V84667	(S,R,S)-AHPC-C3-COOH	2172819-73-5
V82406	(S,R,S)-AHPC-C3-NH2 dihydrochloride (VH032-C3-NH2 dihydrochloride)	2564467-25-8	(S,R,S)-AHPC-C3-NH2 (di-HCl) is the di-HCl salt form of (S,R,S)-AHPC-C3-NH2 .
V82491	(S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2)	2170695-19-7	(S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing the VHL ligand based on VH032 body and 1 linker.
V84649	(S,R,S)-AHPC-C5-NH2 dihydrochloride (VH032-C5-NH2 dihydrochloride)	2415256-20-9
V84528	(S,R,S)-AHPC-C7-amine dihydrochloride (VH032-C7-amine dihydrochloride)	2415256-17-4
V86270	(S,R,S)-AHPC-C7-amine hydrochloride (VH032-C7-amine hydrochloride)	2502189-41-3
V87922	(S,R,S)-AHPC-CO-C9-NH2	2349429-71-4	(S,R,S)-AHPC-CO-C9-NH2 is a Von Hippel-Lindau (VHL) amino building block that can be used to synthesize the E3 ligase ligands required for PROTACs.
V87919	(S,R,S)-AHPC-CO-C9-NH2 hydrochloride	2376139-50-1	(S,R,S)-AHPC-CO-C9-NH2 (hydrochloride) is a von Hippel-Lindau (VHL) amino building block that can be used to synthesize E3 ligase ligands required for PROTACs.
V82344	(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride; E3 ligase Ligand 1 dihydrochloride)	2504950-56-3	(S,R,S)-AHPC-Me di-HCl (VHL ligand 2 di-HCl) is a VHL ligand based on (S,R,S)-AHPC that recruits von Hippel-Lindau (VHL) protein.
V87921	(S,R,S)-AHPC-NHCO-C-O-C5-N3		(S,R,S)-AHPC-NHCO-CO-C5-N3 is a conjugate of E3 ligase ligand and linker.
V77947	(S,R,S)-AHPC-PEG1-OTs (VH032-PEG1-OTs; VHL Ligand-Linker Conjugates 2; E3 ligase Ligand-Linker Conjugates 51)		(S,R,S)-AHPC-PEG1-OTs is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)-AHPC-based VHL ligand and 1 unit PEG linker .
V84609	(S,R,S)-AHPC-PEG3-NH2 dihydrochloride (VH032-PEG3-NH2 dihydrochloride; VHL Ligand-Linker Conjugates 1 dihydrochloride; E3 ligase Ligand-Linker Conjugates 5 dihydrochloride)	2376990-24-6
V84737	(S,R,S)-CO-C2-acid (VH 032 amide-alkylC2-acid)	2172819-72-4
V89494	(S,R,S)-Me-AHPC-amide-C3-alkyne		(S,R,S)-Me-AHPC-amide-C3-alkyne is a conjugate of E3 ligase ligand and linker, which is used to synthesize JWZ-5-13.
V82360	(−)-N-Hydroxyapiosporamide (NHAP)	1205676-02-3	(−)-N-Hydroxyapiosporamide (NHAP) is an alkaloid and an NF-κB inhibitor (antagonist) with potent anticancer effect in vitro and in vivo.
V89513	2-Methoxyphenyl dihydrouracil-azaspiro[5.5]undecane-C-PIP		2-Methoxyphenyl dihydrouracil-azaspiro[5.5]undecane-C-PIP is an E3 ligase ligand-linker conjugate that can be used to synthesize PROTAC SOS1 degrader-10.
V82422	A 410099.1,amine-Boc	1613552-03-6	A 410099.1, amine-Boc is an IAP ligand that may be utilized in the synthesis/preparation of PROTACs, such as PROTACs against BTK (PROTACs 4 and 5).
V82385	Acid-PEG8-SS-PEG8-acid	873013-93-5	Acid-PEG8-SS-PEG8-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.