E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V82449 | (S,R,S)-AHPC-C1-NH2 hydrochloride | 2361120-26-3 | (S,R,S)-AHPC-C1-NH2 HCl is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing a VHL complex based on (S,R,S)-AHPC. body and 1 linker, which may be utilized to prepare PROTAC molecules. | |
V82415 | (S,R,S)-AHPC-C2-PEG3-BCN | 2876198-36-4 | (S,R,S)-AHPC-C2-PEG3-BCN (Compound 16b) is a VHL ligand that may be utilized in the preparation /synthesis of PROTACs | |
V82406 | (S,R,S)-AHPC-C3-NH2 dihydrochloride (VH032-C3-NH2 dihydrochloride) | 2564467-25-8 | (S,R,S)-AHPC-C3-NH2 (di-HCl) is the di-HCl salt form of (S,R,S)-AHPC-C3-NH2 . | |
V82491 | (S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) | 2170695-19-7 | (S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing the VHL ligand based on VH032 body and 1 linker. | |
V82344 | (S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride; E3 ligase Ligand 1 dihydrochloride) | 2504950-56-3 | (S,R,S)-AHPC-Me di-HCl (VHL ligand 2 di-HCl) is a VHL ligand based on (S,R,S)-AHPC that recruits von Hippel-Lindau (VHL) protein. | |
V77947 | (S,R,S)-AHPC-PEG1-OTs (VH032-PEG1-OTs; VHL Ligand-Linker Conjugates 2; E3 ligase Ligand-Linker Conjugates 51) | (S,R,S)-AHPC-PEG1-OTs is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R,S)-AHPC-based VHL ligand and 1 unit PEG linker . | ||
V82360 | (−)-N-Hydroxyapiosporamide (NHAP) | 1205676-02-3 | (−)-N-Hydroxyapiosporamide (NHAP) is an alkaloid and an NF-κB inhibitor (antagonist) with potent anticancer effect in vitro and in vivo. | |
V82422 | A 410099.1,amine-Boc | 1613552-03-6 | A 410099.1, amine-Boc is an IAP ligand that may be utilized in the synthesis/preparation of PROTACs, such as PROTACs against BTK (PROTACs 4 and 5). | |
V82385 | Acid-PEG8-SS-PEG8-acid | 873013-93-5 | Acid-PEG8-SS-PEG8-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
V51687 | AhR Ligand-Linker Conjugates 1 | 2380012-98-4 | AhR Ligand-Linker Conjugates 1 (E3 Ligase Ligand-Linker Conjugates 57) contain IAP ligands and linkers for recruiting E3 ubiquitin ligases. | |
V82339 | Alkaline phosphatase (alkaline phosphatase; Apase) | 9001-78-9 | Alkaline phosphatase (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. | |
V82346 | ALV2 | 2438124-95-7 | ALV2 is a potent and specific Helios degrader. | |
V82411 | Amine-PEG4-Desthiobiotin | 2306109-91-9 | Amine-PEG4-Desthiobiotin is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
V82368 | Amino-PEG11-acid | 1616426-12-0 | Amino-PEG11-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category. | |
V82454 | Amino-PEG6-acetic acid | 1104083-46-6 | Amino-PEG6-acetic acid is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders. | |
V82362 | Amino-PEG7-t-butyl ester | 2428400-07-9 | Amino-PEG7-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders. | |
V82357 | Antiproliferative agent-22 | 1374305-45-9 | antiproliferation agent-22 (compound 2) is an anticancer agent. | |
V82412 | Azido-C1-PEG3-C3-NH2 | 1162336-72-2 | Azido-C1-PEG3-C3-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. | |
V82402 | Azido-PEG3-C6-Cl | 1625717-44-3 | Azido-PEG3-C6-Cl is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules. | |
V82487 | Azido-PEG4-azide | 182760-73-2 | Azido-PEG4-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class. |