Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation.E3 Ligase Binder, Linker, and Target Binder are the components of PROTACs. The Target Binder is a ligand (often a small-molecule inhibitor) for the protein of interest. When the PROTACs attach to the target protein, they can recruit E3 for target protein ubiquitination, which results in proteasome-mediated destruction of the protein. Because of this, PROTACs work by destroying the target proteins rather than blocking them, which is far more effective at overcoming resistance brought on by target mutation or overexpression. In order to overcome resistance, PROTAC technology has been used on a number of targets, including AR, ER, BTK, BET, and BCR-ABL.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2485 | BSJ-4-116 | 2519823-34-6 | BSJ-4-116 is a PROTAC protein degrader linked by Cereblon ligand and CDK ligand. |
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V78571 | BT-PROTAC | BT-PROTAC is a bioorthogonally activated prodrug. | |
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V83053 | Bz-Ala-Arg | 71448-11-8 | Bz-Ala-Arg is a dipeptide. |
|
V70083 | C004019 | 2417159-57-8 | C004019 is a small molecule PROTAC. |
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V78617 | CaMKIIα-PHOTAC | CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) targeting Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). | |
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V83030 | Cbz-PEG2-bromide | 2100283-00-7 | Cbz-PEG2-bromide is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders. |
|
V77160 | CCT367766 formic | CCT367766 formic is a potent orally bioactive protein, a third-generation heterofunctional and Cereblon ligand-based pirin-targeted protein degradation probe (PDP, or PROTAC) that can reduce pirin protein expression at low concentrations. | |
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V37524 | CDK9 Antagonist-1 | CDK9 Antagonist-1 | |
|
V17301 | CM11 (Homo-PROTAC) | 2244684-49-7 | Homo-PROTAC pVHL30 degrader 1 is an effective PROTAC-based pVHL30 degrader. |
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V78867 | CP-07 | CP-07 is a potent and specific PROTAACCDK9 degrader (DC50= 43 nM). | |
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V3476 | dBET1 | 1799711-21-9 | dBET1 is a novel, potent, and competitive CRBN-basedBETdegrader (PROTAC) with an IC50 of 20 nM. |
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V3477 | dBET6 | 1950634-92-0 | dBET6 is a novel, highly potent, selective and cell-permeable chemical degrader ofBET bromodomain proteinsbased onPROTACtechnology with anIC50of 14 nM. |
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V75505 | dBRD9 dihydrochloride | 2341840-98-8 | dBRD9 diHCl is a selective BRD9 PROTAC protein degrader. |
|
V2518 | dCBP-1 | 2484739-25-3 | dCBP-1 is a novel, potent and selective heterobifunctional and PROTAC degrader of p300/CBP with potential anticancer activity. |
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V83058 | DEAE-dextran (MW 40000) (Diethylaminoethyl dextran (MW 40000)) | 9015-73-0 | DEAE-Dextran (MW 40000) is a biochemical compound that could be utilized as a biomaterial or organic/chemical reagent for biomedical research. |
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V83041 | Dovitinib-RIBOTAC | 2759351-68-1 | Dovitinib RIBOTAC is a targeted RNA degrader that cleaves precursor-miR-21 with great potency and selectivity. |
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V29093 | Driselase | 85186-71-6 | Driselase, a mixture ofcell wall degrading enzymes containing ellulase, hemicellulase, pectinase etc, is used for fungal protoplasting enzyme preparation. |
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V3585 | dTRIM 24 | 2170695-14-2 | dTRIM24 is a novel, potent and selective PROTAC degrader ofTRIM24with anticancer activity. |
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V37558 | E3 ligase Ligand 1 dihydrochloride | E3 ligase Ligand 1 dihydrochloride is a compound used in PROTAC technology to recruit E18 ligase. | |
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V37557 | E3 ligase Ligand 13 | E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand. |
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