PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.
A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V82717 | (S,R,S)-AHPC-C7-amine (VH032-C7-amine) | 2306389-04-6 | (S,R,S)-AHPC-C7-amine (VH032-C7-amine) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligand based on VH032 body and 1 linker. |
|
V82735 | (S,R,S)-AHPC-CO-C9-acid (VH032-NH-CO-C9-acid) | 2172819-78-0 | (S,R,S)-AHPC-CO-C9-acid is a ligand (for E3 ligase)-linker conjugate that attaches to a protein's ligand to form a PROTAC. |
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V83015 | (S,R,S)-AHPC-Me-C10-Br | 2836297-55-1 | (S,R,S)-AHPC-Me-C10-Br is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate. |
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V82949 | (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 | 2409538-69-6 | (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthetic E3 ligase ligand conjugate that combines VHL ligand and linker. |
|
V82800 | (S,R,S)-AHPC-Me-decanedioic acid | 2380273-45-8 | (S,R,S)-AHPC-Me-decanedioic acid is a ligand (for E3 ligase)-linker conjugate that may be utilized to prepare PROTAC. |
|
V82826 | (S,R,S)-AHPC-PEG1-NH2 (VH032-PEG1-NH2) | 2241641-57-4 | (S,R,S)-AHPC-PEG1-NH2 (VH032-PEG1-NH2) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligand based on VH032 and 1 linker, which may be utilized to prepare PROTAC molecules. |
|
V82653 | (S,R,S)-AHPC-PEG1-NH2 dihydrochloride (VH032-PEG1-NH2 dihydrochloride) | 2341796-83-4 | (S,R,S)-AHPC-PEG1-NH2 (VH032-PEG1-NH2) di-HCl contains a VHL ligand for E3 ubiquitin ligase and a PROTAC (PROteolysis TArgeting Chimera) linker. |
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V82667 | (S,R,S)-AHPC-PEG3-propionic acid | 2140807-42-5 | (S,R,S)-AHPC-PEG3-propionic acid is a ligand (for E3 ligase )-linker conjugate containing (S,R,S)-AHPC-based VHL ligand and 3 Polyethylene glycol (PEG) units linker. |
|
V83012 | (S,R,S)-AHPC-PEG5-Boc | 2923734-82-9 | (S,R,S)-AHPC-PEG5-Boc is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligands based on (S,R,S)-AHPC and 1 linker. |
|
V82920 | (S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH; VHL Ligand-Linker Conjugates 16; E3 Ligase Ligand-Linker Conjugates 58) | 2172820-14-1 | (S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a ligand (for E3 ligase )-linker conjugate containing (S,R,S)-AHPC-based VHL ligand body and 5-unit PEG linker. |
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V83020 | (S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride (VH032 phenol-alkylC6-amine dihydrochloride) | 2376990-28-0 | (S,R,S)-AHPC-phenol-alkylC6-amine di-HCl is a synthetic E3 ligase ligand-linked conjugate containing a VHL ligand based on VH032 and a linker for PROTAC degradation. |
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V82974 | (S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride (VH032-phenol-C4-NH2 dihydrochloride) | 2376990-26-8 | (S,R,S)-AHPC-phenol-C4-NH2 (VH032-phenol-C4-NH2) di-HCl is an E3 ligase (e.g. CRBN) ligand-linker conjugate, containing S,R,S)-AHPC's VHL ligand and 1 linker may be utilized to prepare PROTAC molecules. |
|
V82957 | 2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride | 1035373-85-3 | 2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (HCl) is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders. |
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V82739 | 3,4-Dibromo-Mal-PEG2-amine TFA | 2296708-07-9 | 3,4-Dibromo-Mal-PEG2-amine TFA is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders. |
|
V82706 | 3-Aminophenol-PEG4-methyl | 1429340-32-8 | 3-Aminophenol-PEG4-methyl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
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V82927 | 4-Azidobutylamine | 88192-20-5 | 4-Azidobutylamine is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the alkyl chain class. |
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V82981 | 5-(Biotinamido)pentylamine | 115416-38-1 | 5-Biotinamidopentylamine is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl chain class, may be utilized to prepare PROTAC protein degraders. |
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V82690 | 5-[Boc(methyl)amino]pentanal | 1620280-47-8 | 5-[Boc(methyl)amino]pentanal is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl/ether class, may be utilized to prepare PROTAC protein degraders. |
|
V38088 | 5-Ethynyl-2'-deoxyuridine | 61135-33-9 | 5-Ethynyl-2'-deoxyuridine (EdU) is a thymidine nucleoside analog that can be inserted into replicating DNA molecules during cell growth/proliferation. |
|
V5631 | 6-Maleimidocaproic acid | 55750-53-3 | 6-Maleimidocaproic acid is a biochemical that contains a maleimide group and a terminal carboxylic acid. |
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