PROTAC Linkers

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PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V78627	Azido-PEG10-CH2CO2-NHS		Azido-PEG10-CH2CO2-NHS is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules.
V79301	Azido-PEG10-CH2COOH		Azido-PEG10-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules.
V78307	Azido-PEG10-propargyl		Azido-PEG10-propargyl is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82703	Azido-PEG11-CH2COOH	2567584-97-6	Azido-PEG11-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules.
V78375	Azido-PEG11-t-butyl ester		Azido-PEG11-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82790	Azido-PEG12-propargyl	2264091-72-5	Azido-PEG12-propargyl is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V78376	Azido-PEG12-THP		Azido-PEG12-THP is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules.
V78337	Azido-PEG13-acid		Azido-PEG13-acid is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V78309	Azido-PEG13-azide		Azido-PEG13-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V78310	Azido-PEG14-t-butyl ester		Azido-PEG14-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V10171	Azido-PEG2-alcohol	139115-90-5	Azido-PEG2-alcohol is a PEG analogue containing an azide group and a terminal hydroxyl group.
V6159	Azido-PEG2-amine	166388-57-4	Azido-PEG2-amine is a PEG analogue containing an amino group with an azide group.
V82965	Azido-PEG2-C6-Cl	2568146-55-2	Azido-PEG2-C6-Cl is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V78313	Azido-PEG2-C6-OH		Azido-PEG2-C6-OH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V12180	Azido-PEG2-CH2CO2H	882518-90-3	Azido-PEG2-CH2CO2H is a PEG analogue containing an azide group with a terminal carboxylic acid.
V82746	Azido-PEG2-propargyl	1245006-63-6	Azido-PEG2-propargyl is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V78311	Azido-PEG20-Boc		Azido-PEG20-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules.
V78312	Azido-PEG23-C2-azide		Azido-PEG23-C2-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82872	Azido-PEG24-acid	2195075-62-6	Azido-PEG24-acid is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82801	Azido-PEG24-alcohol	2415674-94-9	Azido-PEG24-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.