PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.
A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V83009 | 6-Maleimidocaproic acid sulfo-NHS sodium (Sulfo-EMCS) | 215312-86-0 | 6-Maleimidocaproic acid sulfo-NHS (Sulfo-EMCS) sodium is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the alkyl/ether class, may be utilized to prepare PROTAC molecules. |
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V82918 | 7-Octynoic acid | 10297-09-3 | 7-Octynoic acid (compound 42) is a PROTAC (PROteolysis TArgeting Chimera) linker. |
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V82982 | A 410099.1, amine-Boc hydrochloride | 2374122-37-7 | A 410099.1, amine-Boc HCl is an IAP ligand that may be utilized in the synthesis/preparation of PROTACs, such as PROTACs against BTK (PROTACs 4 and 5). |
|
V82629 | A-1210477-piperazinyl (PROTAC Mcl1-binding moiety 1) | 2351218-72-7 | A-1210477-piperazinyl is a compound that binds to the protein myeloid leukemia 1 (MCL1) and is primarily used in PROTAC technology. |
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V82684 | ABM-14 | 1973408-76-2 | ABM-14, a ligand targeting the androgen receptor (AR), was used to design PROTACs. |
|
V77515 | Acetamido-PEG2-Br | Acetamido-PEG2-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V77736 | Acetamido-PEG3-Br | Acetamido-PEG3-Br is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V77762 | Acid-PEG10-t-butyl ester | Acid-PEG10-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders. | |
|
V77763 | Acid-PEG12-CHO | Acid-PEG12-CHO is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V77764 | Acid-PEG12-t-butyl ester | Acid-PEG12-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders. | |
|
V77765 | Acid-PEG14-t-butyl ester | Acid-PEG14-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders. | |
|
V82768 | Acid-PEG3-SSPy | 2088570-69-6 | Acid-PEG3-SSPy is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V77766 | Acid-PEG9-t-butyl ester | Acid-PEG9-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders. | |
|
V82835 | Acryloyl-PEG4-OH | 26150-06-1 | Acryloyl-PEG4-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. |
|
V80154 | ALD-CH2-PEG4-NHBOC | ALD-CH2-PEG4-NHBOC is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
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V82985 | AM-Imidazole-PA-Boc | 2357108-99-5 | AM-Imidazole-PA-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the alkyl chain category. |
|
V80193 | Amine-PEG6-thiol | Amine-PEG6-thiol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders. | |
|
V11099 | Amino-PEG1-t-butyl ester | 1260092-46-3 | Amino-PEG1-t-butyl ester is a PEG analogue containing an amino group with a t-butyl protected carboxyl group. |
|
V78626 | Amino-PEG12-C2-azide | Amino-PEG12-C2-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules. | |
|
V7800 | Amino-PEG2-acid | 791028-27-8 | Amino-PEG2-acid is a PEG analogue containing an amino group with a terminal carboxylic acid. |
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