PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V112909	Undec-10-ynoic acid	2777-65-3	Undecyl-10-alkynic acid (10-undecylalkynic acid) is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112961	Undecane-1,11-diol	765-04-8	Undecane-1,11-diol (1,11-undecanediol) is a PROTAC linker that can be used to synthesize PROTAC molecules.
V77880	VES-POFP		VES-POFP is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82868	VH032 analogue-2	1448189-66-9	VH032 analogue-2 is a VH032 analogue that serves as a ligand for VHL and recruits von Hippel-Lindau (VHL) proteins.
V82810	VH032-C3-Boc	2827750-25-2	VH032-C3-Boc is a Boc-modified VH032 that can serve as a ligand for VHL and recruit von Hippel-Lindau (VHL) protein.
V82687	VH032-CH2-Boc	2827750-24-1	VH032-CH2-Boc is Boc-modified VH032 , which can serve as a ligand of VHL and recruit von Hippel-Lindau (VHL) protein.
V82700	VH032-O-C2-NH-Boc	2409007-41-4	VH032-O-C2-NH-Boc is a Boc-modified VH032 , which can serve as a ligand of VHL and recruit von Hippel-Lindau (VHL) protein.
V82953	VH032-OH	2244684-42-0	VH032-OH is a VHL ligand based on VH032.
V82930	VHL Ligand 8	2701565-76-4	VHL Ligand 8 is a von Hippel-Lindau (VHL) protein ligand.
V82648	VHL Ligand-Linker Conjugates 15 (E3 Ligase Ligand-Linker Conjugates 56)	2375564-62-6	VHL Ligand-Linker Conjugates 15 Contains VHL ligands and linkers for recruiting E3 ubiquitin ligases.
V114099	Z-5-Ava-OH	23135-50-4	Z-5-Ava-OH is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112736	Z-Glycinol	77987-49-6	Z-glycine alcohol (NZ-ethanolamine) is a PROTAC linker that can be used to synthesize PROTAC molecules.
V114145	{3-[(tert-Butyldimethylsilyl)oxy]cyclobutyl}methanol	1394119-83-5	{3-[(tert-butyldimethylsilyl)oxy]cyclobutyl}methanol is a PROTAC linker that can be used to synthesize PROTAC molecules.
V6815	Hydroxy-PEG2-t-butyl ester	133803-81-3	Hydroxy-PEG2-t-butyl ester is a PEG analogue containing a hydroxyl group with a t-butyl ester.
V25910	m-PEG6-alcohol	23601-40-3	m-PEG6-alcohol is a PEG analogue containing a hydroxyl group.
V26300	N-Boc-PEG6-alcohol	331242-61-6	N-Boc-PEG6-alcohol is a PEG analogue containing a hydroxyl group and Boc-protected amino group.
V12183	Azido-PEG3-acid	1056024-94-2	Azido-PEG3-acid (N3-PEG3-CH2CH2COOH) is a novel and potent PEG (polyethyleneglycol) analogueused as a PROTAC linker for the synthesis of BI-3663, BI-4216 and BI-0319.
V12194	Azido-PEG4-acid	1257063-35-6	Azido-PEG4-acid is a PEG analoguecontaining an azide group and is used as aPROTAC linker for the synthesis of Rucaparib-based PARP PROTAC degraders.
V10171	Azido-PEG2-alcohol	139115-90-5	Azido-PEG2-alcohol is a PEG analogue containing an azide group and a terminal hydroxyl group.
V12180	Azido-PEG2-CH2CO2H	882518-90-3	Azido-PEG2-CH2CO2H is a PEG analogue containing an azide group with a terminal carboxylic acid.