PROTACs

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation.E3 Ligase Binder, Linker, and Target Binder are the components of PROTACs. The Target Binder is a ligand (often a small-molecule inhibitor) for the protein of interest. When the PROTACs attach to the target protein, they can recruit E3 for target protein ubiquitination, which results in proteasome-mediated destruction of the protein. Because of this, PROTACs work by destroying the target proteins rather than blocking them, which is far more effective at overcoming resistance brought on by target mutation or overexpression. In order to overcome resistance, PROTAC technology has been used on a number of targets, including AR, ER, BTK, BET, and BCR-ABL.

PROTACs related products

Cat No.	Product Name	CAS No.	Product Description
V80843	MS9715		MS9715 is a potent and specific NSD3 PROTAC.
V70220	MS98	2376137-31-2	MS98 is an effective and selective PROTAC AKT degrader.
V3580	MZ1	1797406-69-9	MZ 1 (MZ1; MZ-1) is a novel and potentPROTAC-based degrader of BRD4protein with anticancer activity.
V3583	MZP-54	2010159-47-2	MZP-54 is a novel, potent and selective PROTAC-based degrader ofBRD3/4with aKdof 4 nM for Brd4BD2.
V83046	N-Boc-piperazine	57260-71-6	N-Boc-piperazine is a PROTAC (PROteolysis TArgeting Chimera) linker of the Alkyl/ether class, may be utilized to prepare PROTAC PD-1/PD-L1 degrader-1 .
V83047	NH2-PEG2-C6-Cl	744203-60-9	NH2-PEG2-C6-Cl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V83036	NH2-PEG2-CH2-Boc	1948273-09-3	NH2-PEG2-CH2-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V74168	NJH-2-056	2858812-69-6	NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) connecting the OTUB1 recruitment factor EN523 and the CFTR chaperone lumacaftor.
V93763	NR-V04	2766608-52-8	NR-V04 is a PROTAC degrader of NR4A1 (red: NR4A1 inhibitor, black: linker, blue: E3 ligase ligand).
V87876	Nrf2 degrader 1	3025286-00-1	Nrf2 degrader 1 (compound 1) is a PROTAC Nrf2 degrader with anticancer activity.
V104643	OICR41114		OICR41114 (PROTAC 4) is a PROTAC degrader targeting WDR5.
V96714	P60-L3-VHL		P60-L3-VHL is a PROTAC-type Foxp3 degrader.
V94127	PCC16 chloride		PCC16 chloride is a CRBN-based cp-PCC with an IC50 value of 102 nM for DHHC3 degradation.
V69499	PF15	2892631-70-6	PF15 is a PROTAC linked by FLT3 kinase ligand and CRBN ligand.
V76637	PF15 TFA		PF15 TFA is a PROTAC linked by FLT3 kinase ligand and CRBN ligand.
V81119	phoBET1		phoBET1 is a photo-sealed PROTAC.
V81123	PhosTAC7	3016307-75-5	Similar to the ability of PROTACs to induce ternary complexes, PhosTAC7 focuses on recruiting Ser/Thr phosphatases to phosphorylated substrates to mediate their dephosphorylation.
V81140	PIK5-12d		PIK5-12d is a PROTAC PIKfyve degrader (DC50= 1.48 nM).
V83032	Pomalidomide-5'-PEG8-C2-COOH	2138440-78-3	Pomalidomide-5'-PEG8-C2-COOH is a ligand (for E3 ligase)-linker conjugate consisting of Pomalidomide and Linker.
V80369	Pomalidomide-5-C2-NH2 hydrochloride		Pomalidomide-5-C2-NH2 (HCl) is a linker conjugate used in the preparation /synthesis of E3 ligase ligand and PROTAC.