PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V105538	tert-Butyl 3-(2-iodoethoxy)propanoate	2296723-16-3	Tert-butyl 3-(2-iodoethoxy) propionate is a PROTAC linker belonging to the PEG class.
V104909	tert-Butyl 4-(4-(piperazin-1-ylmethyl)piperidin-1-yl)benzoate	2566692-49-5	Tert-butyl 4-(4-(piperazin-1-ylmethyl)piperidin-1-yl)benzoate is a PROTAC linker.
V93173	tert-Butyl 4-formylpiperidine-1-carboxylate	137076-22-3	Tert-Butyl 4-formylpiperidine-1-carboxylate is the linker of PROTAC BRM/BRG1 degrader-3.
V97310	tert-Butyl 5-bromoisoindoline-2-carboxylate	201940-08-1	Tert-Butyl 5-bromoisoindoline-2-carboxylate is a PROTAC linker.
V97264	tert-Butyl 9-aminononanoate	134857-22-0	Tert-Butyl 9-aminononanoate is a PROTAC linker.
V82765	Tetraethylene glycol monohexadecyl ether	5274-63-5	Tetraethylene glycol monohexadecyl ether is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82799	TFP-PEG3-TFP	1446282-34-3	TFP-PEG3-TFP is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82633	Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride	2341841-02-7	Thalidomide 4'-oxyacetamide-alkyl-C2-amine HCl combines the E3 ubiquitin ligase ligand cereblon (CRBN) and a linker.
V82914	Thalidomide 5-fluoride	835616-61-0	Thalidomide 5-fluoride is a Cereblon ligand (ligand) based on thalidomide, which binds to the IRAK4 protein ligand through a linker to form PROTAC IRAK4 degrader-1.
V82738	Thalidomide-4-C3-NH2 hydrochloride	2357110-84-8	Thalidomide-4-C3-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V82675	Thalidomide-4-NH-PEG1-NH-Boc	2154342-17-1	Thalidomide-4-NH-PEG1-NH-Boc is a Boc-modified Thalidomide that can serve as a Cereblon ligand to recruit CRBN proteins.
V82836	Thalidomide-4-O-C10-COOH	2379870-45-6	Thalidomide-4-O-C10-COOH is a ligand (for E3 ligase)-linker conjugate that may be utilized in the preparation /synthesis of PROTACs.
V82625	Thalidomide-4-O-C10-NH2	1957236-08-6	Thalidomide-O-C10-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V83021	Thalidomide-4-O-C2-NH2 hydrochloride	2341840-99-9	Thalidomide 4'-ether-alkylC2-amine HCl is a ligand (for E3 ligase )-linker conjugate, containing Thalidomide-based cereblon ligand and linker, used in PROTAC technology.
V82892	Thalidomide-4-O-C3-NH2 hydrochloride	2913240-95-4	Thalidomide-O-C3-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82697	Thalidomide-4-O-C5-NH2	2307477-23-0	Thalidomide-O-C5-NH2 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82910	Thalidomide-4-O-C5-NH2 hydrochloride	2419145-66-5	Thalidomide-O-C5-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.
V82634	Thalidomide-4-O-C7-NH2	2093536-11-7	Thalidomide-O-C7-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V82639	Thalidomide-4-O-C8-NH2	1957235-91-4	Thalidomide-O-C8-NH2 is a ligand (for E3 ligase )-linker conjugate composed of Thalidomide (ligand for E3 ligase cereblon/CRBN) and a linker.
V82897	Thalidomide-4-O-C8-NH2 hydrochloride	2636798-38-2	Thalidomide-O-C8-NH2 HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate, containing Thalidomide-based cereblon ligand and 1 linker, which may be utilized to prepare PROTAC molecules.