PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V82890	Desthiobiotin-PEG4-propargyl	1951424-89-7	Desthiobiotin-PEG4-propargyl is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82721	Diethylene glycol diacetate	628-68-2	Diethylene glycol diacetate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V77801	Dimethylamine-PEG19		Dimethylamine-PEG19 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V79142	Dimethylamino-PEG11		Dimethylamino-PEG11 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V77071	DOTA-PEG5-C6-DBCO		DOTA-PEG5-C6-DBCO is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V83002	Dovitinib-RIBOTAC TFA	2759351-69-2	Dovitinib RIBOTAC TFA is a targeted RNA degrader that cleaves precursor-miR-21 with great potency and selectivity.
V82968	DSPE-PEG-Biotin (MW 2000)	385437-57-0	DSPE-PEG-Biotin (MW 5000) is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V79217	DSPE-PEG14-COOH		DSPE-PEG14-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V77061	DSPE-PEG6-Mal		DSPE-PEG6-Mal is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82942	EED226-COOH	2467965-71-3	EED226-COOH is a EED226-based PROTAC target protein EED ligand, which combines with the VHL ligand through a linker to form the PRC2 degrader UNC6852 .
V79298	endo-BCN-PEG12-NH2 hydrochloride		endo-BCN-PEG12-NH2 HCl is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V87970	endo-BCN-PEG24-NHS ester		Endo-BCN-PEG24-NHS ester is composed of cyclopropane cyclooctyne, twenty-tetramer of polyethylene glycol (PEG) and N-hydroxysuccinimide ester.
V51007	endo-BCN-PEG4-NHS ester	2252422-32-3	endo-BCN-PEG4-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V106738	Ethyl 6-bromohexanoate	25542-62-5	Ethyl 6-bromohexanoate is a linker that can be used to synthesize PROTAC RSS0680.
V99912	Ethyl-trans-4-benzylcyclohexane-1-carboxylate	1923826-92-9	Ethyl-trans-4-benzylcyclohexane-1-carboxylate is a PROTAC linker.
V82851	F-PEG2-COOH	2383964-72-3	F-PEG2-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V79512	F-PEG2-S-Boc		F-PEG2-S-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V77521	F-PEG2-S-COOH		F-PEG2-S-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V77520	F-PEG2-SO-COOH		F-PEG2-SO-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V79513	F-PEG2-SO2-COOH		F-PEG2-SO2-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.