PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V113618	(((6-Bromohexyl)oxy)methyl)benzene	54247-27-7	(((6-bromohexyl)oxy)methyl)benzene is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112849	(((7-Bromoheptyl)oxy)methyl)benzene	94427-22-2	(((7-bromoheptyl)oxy)methyl)benzene is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112842	((2-Iodoethoxy)methyl)benzene	54555-84-9	((2-Iodoethoxy)methyl)benzene is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113089	((3-Bromopropoxy)methyl)benzene	54314-84-0	((3-bromopropoxy)methyl)benzene is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113436	((4-Bromobutoxy)methyl)benzene	60789-54-0	((4-bromobutoxy)methyl)benzene is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112758	((6-Bromohexyl)oxy)(tert-butyl)dimethylsilane	129368-70-3	((6-bromohexyl)oxy)(tert-butyl)dimethylsilane is a PROTAC linker that can be used to synthesize PROTAC molecules.
V82758	(+)-Biotin-PEG2-hydrazide	2413847-26-2	(+)-Biotin-PEG2-hydrazide is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V112808	(1-Boc-4-piperidinyloxy)acetic acid	161948-70-5	(1-Boc-4-piperidinoxy)acetic acid is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113642	(1R,3R)-3-Amino-2,2,4,4-tetramethylcyclobutan-1-ol phosphate	1338812-52-4	(1R,3R)-3-amino-2,2,4,4-tetramethylcyclobut-1-ol phosphate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V107816	(1r,4r)-tert-Butyl 4-(bromomethyl)cyclohexanecarboxylate	2866254-09-1	(1r,4r)-tert-Butyl 4-(bromomethyl)cyclohexanecarboxylate is a PROTAC linker that can be used to synthesize SMD-1087.
V113053	(1s,3s)-3-Amino-2,2,4,4-tetramethylcyclobutyl dihydrogen phosphate		(1s,3s)-3-amino-2,2,4,4-tetramethylcyclobutyl dihydrophosphate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V97230	(1s,4s)-C1-Piperidine-C1-cyclohexane-C1		(1s,4s)-C1-piperidine-C1-cyclohexane-C1 is a PROTAC linker.
V97201	(2-Aminoethyl)carbamic acid	109-58-0	(2-Aminoethyl)carbamic acid is a PROTAC linker belonging to the PEG class.
V102432	(2E)-TCO-PEG4-NHS ester	2269467-44-7	(2E)-TCO-PEG4-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V113764	(2S,3S)-Dimethyl 2,3-dihydroxysuccinate	13171-64-7	(2S,3S)-2,3-dihydroxysuccinate dimethyl ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113965	(3-Aminocyclobutyl)methanol hydrochloride	130369-06-1	(3-Aminocyclobutyl)methanol hydrochloride is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112242	(3-Bromopropoxy)(tert-butyl)dimethylsilane	89031-84-5	(3-Bromopropoxy)(tert-butyl)dimethylsilane is a PROTAC linker that can be used to synthesize PROTAC molecules.
V105574	(3R)-3-Pyrrolidinemethanol	110013-18-8	Molecular building blocks and linkers of (3R)-3-pyrrolidinemethanol NRX-0492.
V112930	(4-(((1-(Tert-butoxycarbonyl)piperidin-4-yl)oxy)methyl)phenyl)boronic acid	1224449-13-1	(4-(((1-(tert-Butoxycarbonyl)piperidin-4-yl)oxy)methyl)phenyl)boronic acid is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112936	(4-(((Tert-butoxycarbonyl)(methyl)amino)methyl)phenyl)boronic acid	1287753-35-8	(4-(((tert-Butoxycarbonyl)(methyl)amino)methyl)phenyl)boronic acid is a PROTAC linker that can be used to synthesize PROTAC molecules.