PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V82758	(+)-Biotin-PEG2-hydrazide	2413847-26-2	(+)-Biotin-PEG2-hydrazide is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V107816	(1r,4r)-tert-Butyl 4-(bromomethyl)cyclohexanecarboxylate	2866254-09-1
V97230	(1s,4s)-C1-Piperidine-C1-cyclohexane-C1		(1s,4s)-C1-piperidine-C1-cyclohexane-C1 is a PROTAC linker.
V97201	(2-Aminoethyl)carbamic acid	109-58-0	(2-Aminoethyl)carbamic acid is a PROTAC linker belonging to the PEG class.
V102432	(2E)-TCO-PEG4-NHS ester	2269467-44-7	(2E)-TCO-PEG4-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V105574	(3R)-3-Pyrrolidinemethanol	110013-18-8
V104448	(4-(1H-1,2,3-Triazol-4-yl)phenyl)methanol	2149801-20-5
V82861	(E)-TCO-PEG4-NHS ester	1621096-79-4	(E)-TCO-PEG4-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V104323	(R)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline
V82748	(R)-Pomalidomide-pyrrolidine	2418618-52-5	(R)-Pomalidomide-pyrrolidine, a CRBN ligand, can be linked to protein ligands through linkers to produce PROTACs.
V79359	(R)-TCO4-PEG2-Maleimide		TCO4-PEG2-Maleimide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V80303	(R)-TCO4-PEG2-NH2		(R)-TCO4-PEG2-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V79045	(R)-TCO4-PEG3-Maleimide		TCO4-PEG3-Maleimide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V78842	(R)-TCO4-PEG7-NH2		(R)-TCO4-PEG7-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82641	(Rac)-PROTAC PARP/EGFR ligand 1	2935073-36-0	(Rac)-PROTAC PARP/EGFR ligand 1 Contains ligands for the target proteins PARP and EGFR, and a PROTAC (PROteolysis TArgeting Chimera) linker that recruits E3 ligases such as VHL, CRBN, MDM2, and IAP.
V104283	(S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline
V96698	(S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-CH2-Me-PIP-Boc	3043672-77-8	(S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-CH2-Me-PIP-Boc is the E3 ligase ligand and PROTAC linker of PROTAC K-Ras Degrader-3.
V107099	(S)-NH2-Pyridine-piperazine(Me)-Boc	1433849-58-1
V79046	(S)-TCO-PEG3-maleimide		(S)-TCO-PEG3-maleimide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V79980	(S,E)-TCO2-PEG3-acid		(S)-TCO-PEG3-acid is a click chemistry PEG linker with a terminal carboxylic acid (COOH) group.