PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V112240	rel-(1r,4r)-4-Aminocyclohexane-1-carbonitrile hydrochloride	873537-33-8	rel-(1r,4r)-4-aminocyclohexane-1-nitrile hydrochloride is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112774	rel-(1S,2R)-2-(((tert-butoxycarbonyl)amino)methyl)cyclopropane-1-carboxylic acid	1638768-80-5	rel-(1S,2R)-2-(((tert-Butoxycarbonyl)amino)methyl)cyclopropane-1-carboxylic acid is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113062	rel-(3S,4S)-1-(tert-Butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid	1903422-62-7	rel-(3S,4S)-1-(tert-Butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid is a PROTAC linker that can be used to synthesize PROTAC molecules.
V81297	Rhodamine B PEG2-NH2		Rhodamine B PEG2-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82813	S-acetyl-PEG4-NHBoc	1404111-70-1	S-acetyl-PEG4-NHBoc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80256	S-acetyl-PEG4-Thiol		S-acetyl-PEG4-Thiol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82863	S-acetyl-PEG5-alcohol	1000415-61-1	S-acetyl-PEG5-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82959	SB1-G-187	2769753-18-4	SB1-G-187 is a PROTAC, a multikinase degrader.
V82845	SCO-PEG3-COOH	2141976-36-3	SCO-PEG3-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82714	SCO-PEG8-NHS	2143968-68-5	SCO-PEG8-NHS SCO is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V114057	Sodium 2-(2-hydroxyethoxy)acetate	142047-97-0	Sodium 2-(2-hydroxyethoxy)acetate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113452	Sodium 5-hydroxypentanoate	37435-69-1	Sodium 5-hydroxyvalerate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V82973	SR-1114	2769141-82-2	SR-1114 is a first-of-its-kind PROTAC ENL degrader.
V76469	Sulfo DBCO-PEG4-Maleimide TEA		Sulfo DBCO-PEG4-Maleimide TEA is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V113754	Sulfonic chloride-C4-COOMe	1408058-14-9	Sulfonate chloride-C4-COOMe is a PROTAC linker that can be used to synthesize PROTAC molecules.
V81543	t-Boc-amido-PEG10-acid		t-Boc-amido-PEG10-acid is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V82787	t-Boc-Aminooxy-PEG11-amine	1630094-83-5	t-Boc-Aminooxy-PEG11-amine is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V82674	t-Boc-N-amido-PEG10-Br	2787474-57-9	t-Boc-N-amido-PEG10-Br is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V81544	t-Boc-N-amido-PEG15-Br		t-Boc-N-amido-PEG15-Br is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V82770	t-Boc-N-amido-PEG2-C6-Cl	920264-35-3	t-Boc-N-amido-PEG2-C6-Cl is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.