PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V82768	Acid-PEG3-SSPy	2088570-69-6	Acid-PEG3-SSPy is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V77766	Acid-PEG9-t-butyl ester		Acid-PEG9-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V82835	Acryloyl-PEG4-OH	26150-06-1	Acryloyl-PEG4-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80154	ALD-CH2-PEG4-NHBOC		ALD-CH2-PEG4-NHBOC is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V101468	Alkyne-C6-OMs	228403-45-0	Alkyne-C6-OMs is a PROTAC linker that can be used to synthesize PROTACs.
V82985	AM-Imidazole-PA-Boc	2357108-99-5	AM-Imidazole-PA-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the alkyl chain category.
V105600	AMCA	701-54-2	AMCA (4-(Aminomethyl)-1-cyclohexanecarboxylic acid) is a PROTAC linker.
V80193	Amine-PEG6-thiol		Amine-PEG6-thiol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V103074	Amine-PEG6-thiol hydrochloride		Amine-PEG6-thiol hydrochloride is a PROTAC linker belonging to the PEG class.
V11099	Amino-PEG1-t-butyl ester	1260092-46-3	Amino-PEG1-t-butyl ester is a PEG analogue containing an amino group with a t-butyl protected carboxyl group.
V78626	Amino-PEG12-C2-azide		Amino-PEG12-C2-azide is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG category, may be utilized to prepare PROTAC molecules.
V77919	Amino-PEG2-CH2CH2-SH hydrochloride		Amino-PEG2-CH2CH2-SH (HCl) is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82850	Amino-PEG24-acid	2563873-76-5	Amino-PEG24-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V5760	Amino-PEG3-alcohol	6338-55-2	Amino-PEG3-alcohol is a PEG analogue containing an amino group with a hydroxyl group.
V77922	Amino-PEG4-C2-SH hydrochloride		Amino-PEG4-C2-SH HCl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V5620	Amino-PEG4-t-butyl ester	581065-95-4	Amino-PEG4-t-butyl ester is a PEG analogue containing an amino group with a t-butyl protected carboxyl group.
V7830	Amino-PEG6-alcohol	39160-70-8	Amino-PEG6-alcohol is a PEG analogue containing an amino group with a hydroxyl group.
V77923	Amino-PEG7-C2-SH hydrochloride		Amino-PEG7-C2-SH HCl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82771	Aminooxy-PEG8-acid	2055269-60-6	Aminooxy-PEG8-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V101268	Aniline-piperazine-C3-NH-Boc	643087-19-8	Aniline-piperazine-C3-NH-Boc (compound Int-3) is a PROTAC linker that can be used to synthesize pomalidomide-C3-adavosertib and AZD1775 (a Wee1 inhibitor).