PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V107060	2-(3-(Aminomethyl)phenyl)acetic acid	113520-43-7	2-(3-(Aminomethyl)phenyl)acetic acid is a PROTAC linker that can be used to synthesize DU-14 (PTP1B/TC-PTP PROTAC).
V82739	3,4-Dibromo-Mal-PEG2-amine TFA	2296708-07-9	3,4-Dibromo-Mal-PEG2-amine TFA is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V25849	m-PEG3-amine	74654-07-2	m-PEG3-amine is a PEG analogue containing an amino group.
V97263	3,8-Diazabicyclo[3.2.1]octane-4-pyrimidine-piperidine-cyclohexene-Bpin		3,8-Diazabicyclo[3.2.1]octane-4-pyrimidine-piperidine-cyclohexene-Bpin is a PROTAC linker.
V97346	3,8-Diazabicyclo[3.2.1]octane-pyrimidine-piperidine-cyclohexene-Bpin		3,8-Diazabicyclo[3.2.1]octane-pyrimidine-piperidine-cyclohexene-Bpin is a PROTAC linker.
V104442	3-(2-(4-Methylpiperazin-1-yl)ethyl)azetidin-3-ol	1782009-18-0	3-(2-(4-Methylpiperazin-1-yl)ethyl)azetidin-3-ol is the linker of BRD4 PROTAC BD-9136.
V107815	3-(Dimethoxymethyl)-1-oxa-8-azaspiro[4.5]decane	3026011-77-5	3-(Dimethoxymethyl)-1-oxa-8-azaspiro[4.5]decane is a PROTAC linker that can be used to synthesize ERD-1233.
V82706	3-Aminophenol-PEG4-methyl	1429340-32-8	3-Aminophenol-PEG4-methyl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V97438	3-Azaspiro[5.5]undecane-9-methanol	1784372-01-5	3-Azaspiro[5.5]Undecane-9-methanol is a PROTAC linker.
V102268	3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde	1416176-14-1	3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde is a PROTAC linker that can be used to synthesize PROTAC SOS1 degrader-8.
V93743	3-Hydroxyazetidine-Cyclohexanol	1553176-51-4	3-Hydroxyazetidine-cyclohexanol is a PROTAC linker that can be used to synthesize ALK PROTACs.
V25864	m-PEG4-acid	67319-28-2	m-PEG4-acid is a PEG analogue containing a terminal carboxylic acid.
V97253	4-(1,3-Dioxolan-2-yl)phenethyl methanesulfonate	2369046-75-1	4-(1,3-Dioxolan-2-yl)phenethyl methanesulfonate is a PROTAC linker.
V82927	4-Azidobutylamine	88192-20-5	4-Azidobutylamine is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the alkyl chain class.
V82981	5-(Biotinamido)pentylamine	115416-38-1	5-Biotinamidopentylamine is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl chain class, may be utilized to prepare PROTAC protein degraders.
V82690	5-[Boc(methyl)amino]pentanal	1620280-47-8	5-[Boc(methyl)amino]pentanal is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl/ether class, may be utilized to prepare PROTAC protein degraders.
V93897	5-Amino-N-(3-bromopropyl)pentanamide	2848129-72-4	5-Amino-N-(3-bromopropyl)pentanamide is a PROTAC linker that can be used to synthesize PROTAC TBL1X degrader-1.
V102186	5-Bromopentanoyl chloride	4509-90-4	5-Bromopentanoyl chloride is the PROTAC linker in PROTAC ATR Degrader-2 and can be used to synthesize PROTACs.
V102968	5-Hexynal	29329-03-1	5-Hexynal (Compound 3) is a PROTAC linker that can be used to prepare the PROTAC product iRucaparib-TP3.
V38088	5-Ethynyl-2'-deoxyuridine	61135-33-9	5-Ethynyl-2'-deoxyuridine (EdU) is a thymidine nucleoside analog that can be inserted into replicating DNA molecules during cell growth/proliferation.