PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V79299	MS-PEG8-THP		MS-PEG8-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82761	MS6105	2891709-58-1	MS6105 is an LDH proteolytic targeting chimera (PROTAC) that effectively degrades LDHA and LDHB in a time- and ubiquitin-proteasome system-dependent manner and has anti-neoplastic activity.
V94416	N-(7-Aminoheptyl)-2-bromoacetamide	2863663-69-6	N-(7-aminoheptyl)-2-bromoacetamide is a PROTACT linker.
V76730	N-(Amino-PEG2)-N-bis(PEG3-azide)		N-(Amino-PEG2)-N-bis(PEG3-azide) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82788	N-(m-PEG4)-N'-(PEG3-Mal)-Cy5	2839527-02-3	N-(m-PEG4)-N'-(PEG3-Mal)-Cy5 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80891	N-Acetylpyrrolidine-PEG2-Br		N-Acetylpyrrolidine-PEG2-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80901	N-bis(t-boc-N-amido-PEG3)-N-(PEG3-acid) (hydrochloride)		N-bis(t-boc-N-amido-PEG3)-N-(PEG3-acid) HCl is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82944	N-Boc-C1-PEG3-C3-NH2	194920-62-2	N-Boc-C1-PEG3-C3-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82726	N-Boc-C1-PEG5-C3-NH2	956472-77-8	N-Boc-C1-PEG5-C3-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82683	N-Boc-PEG-t-butyl ester	145119-18-2	N-Boc-PEG-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V26295	N-Boc-PEG3-alcohol	139115-92-7	N-Boc-PEG3-alcohol is a PEG analogue containing a hydroxyl group and Boc-protected amino group.
V80902	N-Boc-PEG3-t-butyl ester		N-Boc-PEG3-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V26297	N-Boc-PEG4-alcohol	106984-09-2	N-Boc-PEG4-alcohol is a PEG analogue containing a hydroxyl group and Boc-protected amino group.
V26299	N-Boc-PEG5-alcohol	1404111-67-6	N-Boc-PEG5-alcohol is a PEG analogue containing a hydroxyl group and Boc-protected amino group.
V82849	N-Deshydroxyethyl Dasatinib-d8	1189998-96-6	N-Deshydroxyethyl Dasatinib-d8 is the deuterated form of N-Deshydroxyethyl Dasatinib.
V80408	N-Ethyl-3,3,3-trifluoro-N-methylpropanamide-PEG2-Br		N-Ethyl-333-trifluoro-N-methylpropanamide-PEG2-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82685	N-Ethyl-N-methylpropionamide-PEG1-Br	1695856-63-3	N-Ethyl-N-methylpropionamide-PEG1-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80929	N-Ethylacetamide-PEG1-Br		N-Ethylacetamide-PEG1-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V77516	N-Ethylacetamide-PEG2-Br		N-Ethylacetamide-PEG2-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V97361	N-Ethylheptanamide	54007-34-0	N-ethylheptylamide is a PROTAC linker.