PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V80452	Boc-Pyrrolidine-PEG2-COOH		Boc-Pyrrolidine-PEG2-COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82883	BocNH-PEG5-CH2CH2Br	1392499-33-0	BocNH-PEG5-CH2CH2Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V97368	Bpin-Cyclohexene-C-COOEt	1166829-70-4	Bpin-Cyclohexene-C-COOEt is a PROTAC linker.
V98856	Bpin-Cyclohexene-COOEt	1049004-32-1	Bpin-cyclohexene-COOEt (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexene-1-carboxylic acid ethyl ester) is a PROTAC linker belonging to the PEG class.
V82691	Br-Boc-C2-azido	1120364-53-5	Br-Boc-C2-azido is a PROTAC (PROteolysis TArgeting Chimera) linker, belonging to the alkyl/ether category, may be utilized to prepare PROTAC molecules.
V82971	Br-C3-methyl ester	4897-84-1	Br-C3-methyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the alkyl/ether class, may be utilized to prepare PROTAC PD-1/PD-L1 degrader-1 .
V105023	Br-C4-NHBoc	1690587-08-6	Br-C4-NHBoc is a PROTAC linker that can be used to synthesize CCW 28-3.
V77418	Br-PEG2-oxazolidin-2-one		Br-PEG2-oxazolidin-2-one is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78562	Br-PEG3-MS		Br-PEG3-MS is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80397	Br-PEG4-acid		Br-PEG4-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82854	Br-PEG6-C2-acid	309916-91-4	Br-PEG6-C2-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82724	Br-PEG6-CH2COOtBu	297162-48-2	Br-PEG6-CH2COOtBu is a PROTAC (PROteolysis TArgeting Chimera) linker, which belongs to the Polyethylene glycol (PEG) category and may be utilized to prepare PROTAC protein degraders.
V78563	Br-PEG7-NHBoc		Br-PEG7-NHBoc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78564	Br-PEG9-C2-NHBoc		Br-PEG9-C2-NHBoc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82847	Brigatinib C	1197958-75-0	Brigatinib C is the linker portion of HJM-561 assembled into PROTAC.
V82816	Bromo-C10-OBn	78277-30-2	Bromo-C10-OBn is a PROTAC (PROteolysis TArgeting Chimera) linker that may be utilized to prepare PROTAC.
V80040	Bromo-C4-PEG4-t-butyl ester		Bromo-C4-PEG4-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V82806	Bromo-PEG1-NH2 hydrobromide	2287287-20-9	Bromo-PEG1-NH2 HBr is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V78555	Bromo-PEG10-t-butyl ester		Bromo-PEG10-t-butyl ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V78556	Bromo-PEG12-acid		Bromo-PEG12-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.