Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V79818	HOXB7 8–25 (MDM2 32-46)		HOXB7 8–25 (MDM2 32–46) is an MDM2-derived peptide epitope that elicits antigen-specific and tumor-reactive CD4+ T cell responses.
V104619	L321		4-Methylphenoxyacetic acid-Oxindole-CF3 is the E3 ligase ligand portion of L134.
V80546	LCL-PEG3-N3		LCL-PEG3-N3 is a decoy oligonucleotide E3 ligase ligand that may be utilized to develop chimeric molecules LCL-ER(dec) to degrade estrogen receptors.
V80547	LCL-PEG3-N3 hydrochloride		LCL-PEG3-N3 ( HCl) is a decoy oligonucleotide E3 ligase ligand that may be utilized to develop chimeric molecules LCL-ER(dec) to degrade estrogen receptors.
V84791	Lenalidomide 4'-alkyl-C3-azide	2399455-71-9
V84868	Lenalidomide 4'-alkyl-C5-azide	2399455-78-6
V84798	Lenalidomide 4'-PEG1-amine dihydrochloride	2624336-86-1
V84823	Lenalidomide 4'-PEG2-amine dihydrochloride	2624336-88-3
V84544	Lenalidomide 4'-PEG2-azide	2399455-48-0
V84792	Lenalidomide 4'-PEG3-amine dihydrochloride	2624336-87-2
V83671	Lenalidomide 5'-piperazine	2222120-31-0
V83669	Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride	2520105-60-4
V80239	Lenalidomide sodium (lenalidomide sodium; CC-5013 sodium)		Lenalidomide (sodium) is an analogue of Thalidomide and an orally bioactive immunomodulator that acts like a molecular glue.
V85047	Lenalidomide-C5-acid	2338824-30-7
V106719	Lenalidomide-F	2359705-88-5	Lenalidomide-F is the E3 ligase ligand of LWY713, a PROTAC-based FLT3 degrader (DC50 = 0.64 nM) that selectively induces FLT3 degradation in a brain cell- and proteasome-dependent manner.
V40200	Lenalidomide-OH	1416990-08-3	Lenalidomide-OH, a hydroxylated analog of Lenalidomide which is a cereblon (CRBN) ligand usedfor E3 ubiquitin ligase, can be used as a E3 ligase ligand in PROTACs for the recruitment of CRBN protein.
V82587	m-PEG3-S-PEG1-C2-Boc	2365419-97-0	m-PEG3-S-PEG1-C2-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82571	m-PEG5-Propyne	1101668-41-0	m-PEG5-Propyne is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class, may be utilized to prepare PROTAC molecules.
V82536	Mal-amido-PEG24-acid	2171095-70-6	Mal-amido-PEG24-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82591	Mal-amido-PEG9-NHS ester	2575631-92-2	Mal-amido-PEG9-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.