PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V113890	tert-Butyl 6-(hydroxymethyl)-2-azaspiro[3.3]heptane-2-carboxylate	1363381-93-4	tert-Butyl 6-(hydroxymethyl)-2-azaspiro[3.3]heptane-2-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113421	tert-Butyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate	1211586-09-2	tert-Butyl-6-amino-2-azaspiro[3.3]heptane-2-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112862	tert-Butyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate hydrochloride	1414958-13-6	tert-Butyl-6-amino-2-azaspiro[3.3]heptane-2-carboxylic acid hydrochloride is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113048	tert-Butyl 6-amino-2-azaspiro[3.4]octane-2-carboxylate	1638763-38-8	tert-Butyl-6-amino-2-azaspiro[3.4]octane-2-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113791	tert-Butyl 6-benzyl-2,6-diazaspiro[3.4]octane-2-carboxylate	1352926-14-7	tert-Butyl-6-benzyl-2,6-diazaspiro[3.4]octane-2-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V114082	tert-Butyl 6-formyl-2-azaspiro[3.3]heptane-2-carboxylate	1440960-67-7	tert-Butyl-6-formyl-2-azaspiro[3.3]heptane-2-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113074	tert-Butyl 6-hydroxy-2-azaspiro[3.4]octane-2-carboxylate	1363381-95-6	tert-butyl-6-hydroxy-2-azaspiro[3.4]octane-2-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113498	tert-Butyl 6-iodohexanoate	67899-04-1	tert-butyl 6-iodohexanoate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V114104	tert-Butyl 7-(aminomethyl)-2-azaspiro[3.5]nonane-2-carboxylate	1638767-03-9	tert-Butyl 7-(aminomethyl)-2-azaspiro[3.5]nonane-2-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112627	tert-Butyl 7-(aminomethyl)-2-azaspiro[4.4]nonane-2-carboxylate	1341036-75-6	tert-Butyl 7-(aminomethyl)-2-azaspiro[4.4]nonane-2-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V114014	tert-Butyl 7-(hydroxymethyl)-2-azaspiro[3.5]nonane-2-carboxylate	1434141-69-1	tert-Butyl 7-(hydroxymethyl)-2-azaspiro[3.5]nonane-2-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112603	Tert-butyl 7-(prop-2-yn-1-yl)-2,7-diazaspiro[3.5]Nonane-2-carboxylate	2434850-33-4	tert-Butyl 7-(prop-2-yn-1-yl)-2,7-diazaspiro[3.5]nonane-2-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112597	tert-Butyl 7-aminoheptanoate	105974-64-9	tert-butyl 7-aminoheptane ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113713	tert-Butyl 7-iodoheptanoate	54005-76-4	tert-butyl 7-iodoheptane ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113142	tert-Butyl 8-amino-2-azaspiro[4.5]decane-2-carboxylate	1363381-61-6	tert-Butyl-8-amino-2-azaspiro[4.5]decane-2-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113467	tert-Butyl 8-aminooctanoate	102522-32-7	tert-butyl 8-aminooctanoate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113051	tert-Butyl 8-bromooctanoate	77383-17-6	tert-butyl 8-bromooctanoate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V114184	tert-Butyl 8-hydroxyoctanoate	401901-41-5	tert-butyl 8-hydroxyoctanoate is a PROTAC linker that can be used to synthesize PROTACs, such as PROTAC CDK degrader-1.
V114101	tert-Butyl 9-amino-3-azaspiro[5.5]undecane-3-carboxylate	1272758-41-4	tert-Butyl 9-amino-3-azaspiro[5.5]undecane-3-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V97264	tert-Butyl 9-aminononanoate	134857-22-0	Tert-Butyl 9-aminononanoate is a PROTAC linker.