PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V109224	tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride	1023301-84-9	tert-Butyl 2,7-diazaspiro[3.5]nonane-7-carboxylic acid hydrochloride is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112152	tert-Butyl 2,7-diazaspiro[4.4]nonane-2-carboxylate oxalate(2:1)	1788054-69-2	tert-Butyl-2,7-diazaspiro[4.4]nonane-2-carboxylic acid oxalate (2:1) is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113497	tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate	336191-17-4	tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113470	tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate hydrochloride	869976-20-5	tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylic acid hydrochloride is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113348	tert-Butyl 2-(2-aminoethyl)-2,7-diazaspiro[3.5]nonane-7-carboxylate dihydrochloride	2173991-85-8	tert-Butyl 2-(2-aminoethyl)-2,7-diazaspiro[3.5]nonane-7-carboxylic acid ester (dihydrochloride) is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113817	Tert-butyl 2-(2-aminoethyl)-2,8-diazaspiro[4.5]Decane-8-carboxylate	1420876-70-5	2-(2-aminoethyl)-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113659	tert-Butyl 2-(2-bromoethyl)-7-azaspiro[3.5]nonane-7-carboxylate	2434847-28-4	tert-butyl 2-(2-bromoethyl)-7-azaspiro[3.5]nonane-7-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113414	Tert-butyl 2-(2-hydroxyethyl)-7-azaspiro[3.5]Nonane-7-carboxylate	1370210-93-7	2-(2-hydroxyethyl)-7-azaspiro[3.5]nonane-7-carboxylic acid tert-butyl ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113131	tert-Butyl 2-(2-iodoethoxy)acetate	1401351-72-1	tert-butyl 2-(2-iodoethoxy)acetate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V114094	tert-Butyl 2-(4-aminophenyl)acetate	174579-31-8	tert-Butyl 2-(4-aminophenyl)acetic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113992	tert-Butyl 2-(hydroxymethyl)-7-azaspiro[3.5]nonane-7-carboxylate	1356476-27-1	tert-butyl 2-(hydroxymethyl)-7-azaspiro[3.5]nonane-7-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112832	tert-Butyl 2-(piperazin-1-yl)acetate hydrochloride	2408342-38-9	tert-Butyl 2-(piperazin-1-yl)acetic acid hydrochloride is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113017	tert-Butyl 2-(piperidin-4-yl)acetate	180182-07-4	tert-Butyl 2-(piperidin-4-yl)acetate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113428	tert-Butyl 2-(piperidin-4-yl)acetate hydrochloride	2174007-91-9	tert-Butyl 2-(piperidin-4-yl)acetic acid hydrochloride is a PROTAC linker that can be used to synthesize PROTAC molecules.
V114096	tert-Butyl 2-(piperidin-4-yl)acetate oxalate	1360438-13-6	tert-Butyl 2-(piperidin-4-yl)acetic oxalate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113903	tert-Butyl 2-azaspiro[3.3]heptan-6-ylcarbamate	1118786-85-8	tert-butyl-2-azaspiro[3.3]heptane-6-ylcarbamate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V114112	tert-Butyl 2-azaspiro[3.3]heptan-6-ylcarbamate oxalate(2:1)	1523572-07-7	tert-Butyl 2-azaspiro[3.3]heptane-6-ylcarbamate oxalate (2:1) is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113907	tert-Butyl 2-bromo-7-azaspiro[3.5]nonane-7-carboxylate	1225276-07-2	tert-butyl-2-bromo-7-azaspiro[3.5]nonane-7-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113481	tert-Butyl 2-cyano-7-azaspiro[3.5]nonane-7-carboxylate	203662-66-2	tert-butyl-2-cyano-7-azaspiro[3.5]nonane-7-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V114006	tert-Butyl 2-formyl-6-azaspiro[3.4]octane-6-carboxylate	203662-55-9	tert-Butyl-2-formyl-6-azaspiro[3.4]octane-6-carboxylic acid ester is a PROTAC linker that can be used to synthesize PROTAC molecules.