PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V112853	Methyl 7-aminoheptanoate	39979-08-3	Methyl 7-aminoheptanate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112740	Methyl 7-aminoheptanoate hydrochloride	17994-94-4	7-Aminoheptanoic acid methyl ester hydrochloride is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113377	Methyl 7-bromoheptanoate	54049-24-0	Methyl 7-bromoheptanoate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112728	Methyl 8-bromooctanoate	26825-92-3	Methyl 8-bromooctanoate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112833	Methyl 8-oxooctanoate	3884-92-2	Methyl 8-oxooctanoate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112725	Methyl 9-bromononanoate	67878-15-3	Methyl 9-bromononanoate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V82709	Methyl acetate-PEG1	58349-37-4	Methyl acetate-PEG1 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80895	Methyl acetate-PEG2-propanol		Methyl acetate-PEG2-propanol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V113024	Methyl benzenesulfonic acid-PEG3-O-NO2	1973503-48-8	Methylbenzenesulfonic acid-PEG3-O-NO2 is a PROTAC linker that can be used to synthesize PROTAC molecules.
V114097	Methyl N-(3-methoxy-3-oxopropyl)-N-methyl-beta-alaninate	105-71-5	Methyl N-(3-methoxy-3-oxopropyl)-N-methyl-β-alanine ester is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113900	Methyl N-Boc-4-piperidinepropionate	162504-75-8	Methyl N-Boc-4-piperidinyl propionate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113113	Methyl-Bn-PEG3-OH	138471-93-9	Methyl-Bn-PEG3-OH is a PROTAC linker that can be used to synthesize PROTAC molecules.
V82713	Methyl-PEG2-alcohol	111-77-3	Methyl-PEG2-alcohol is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80885	Methylacetamide-PEG3-NH2		Methylacetamide-PEG3-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82736	Methylamino-PEG3-acid	2148295-95-6	Methylamino-PEG3-acid is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V80759	Methylamino-PEG7-benzyl		Methylamino-PEG7-benzyl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V76762	ML 2-14		ML 2-14 is a PROTAC for BRD4 degradation with a C4 alkyl linker.
V82693	MS-PEG10-THP	42607-91-0	MS-PEG10-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82698	MS-PEG12-THP	552886-58-5	MS-PEG12-THP is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V82791	Ms-PEG3-CH2CH2COOH	2306832-21-1	Ms-PEG3-CH2CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.