PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V82719	Nonylbenzene-PEG8-OH	41506-14-3	Nonylbenzene-PEG8-OH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V104469	Octane-1,8-diamine-Glycolic acid	167613-63-0	Octane-1,8-diamine-glycolic acid is a PROTAC linker that can be used to synthesize PROTAC molecules for research in the field of cancer.
V99925	OH-C2-PEG3-NHCO-C3-COOH		OH-C2-PEG3-NHCO-C3-COOH is a PROTAC linker that can be used to synthesize PROTAC.
V104563	OH-PEG3-C2-Succinamic acid-2-(Methylamino)ethanol		OH-PEG3-C2-succinamic acid-2-(methylamino)ethanol is a PROTAC linker that can be used to synthesize PROTAC tamoxifen-PEG-clozapine.
V97348	OMs-PEG2-NHAlloc-PEG2-Boc	2376332-47-5	OMs-PEG2-NHAlloc-PEG2-Boc is a PROTAC linker.
V82884	PEG3	67439-82-1	PEG3 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V4561	PF-05231023	1037589-69-7	PF-05231023 is novel and potent, long-actingFGF21-receptoragonist being developed as a potential treatment for T2DM.
V82730	Ph-PEG3	7204-16-2	Ph-PEG3 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V79321	Phthalimide-PEG4-MPDM-OH		Phthalimide-PEG4-MPDM-OH is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V81125	Phthalimide-PEG4-PDM-OTBS		Phthalimide-PEG4-PDM-OTBS is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V102302	PIP-C-3-Azaspiro[5.5]undecane-boc	3027978-51-1	PIP-C-3-Azaspiro[5.5]undecane-boc is the linker of PROTAC.
V97258	Piperazine-Ac-OMe	82516-17-4	Piperazine-Ac-OMe is a PROTAC linker.
V97432	Piperazine-Pyrimidine-Cyclohexane-COOEt		Piperazine-pyrimidine-cyclohexane-COOEt is a PROTAC linker.
V94563	Piperidin-4-amine-C5-O-C1	1098625-76-3	Piperidin-4-amine-C5-O-C1 is a PROTAC (compound D4) linker that can be used to synthesize PROTAC molecules.
V101736	Piperidine-4-carbaldehyde	50675-20-2	Piperidine-4-carboxaldehyde is a PROTAC Linker used to optimize the binding affinity with the target protein, thereby improving the degradation efficiency of PROTAC molecules and can be used for the synthesis of CDK2 PROTAC.
V104466	Piperidine-C-Pip-C2-Pip-C2-OH		Piperidine-C-Pip-C2-Pip-C2-OH is a PROTAC linker that can be used to synthesize PROTAC PARP1 degrader-3 for cancer research.
V104355	Piperidine-C2-piperazine-Boc	2222119-35-7	Piperidine-C2-piperazine-Boc is a PROTAC linker that can be used to synthesize PROTACs.
V82645	Piperidine-GNE-049-N-Boc	1936431-36-5	Piperidine-GNE-049-N-Boc is a ligand for the PROTAC target protein of dCBP-1.
V82926	Pomalidomide 4'-alkylC5-acid	2225940-49-6	Pomalidomide 4'-alkylC5-acid (Example 3) is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing Pomalidomide based cereblon (CRBN) ligand and 1 linker.
V82934	Pomalidomide 4'-PEG2-azide	2271036-45-2	Pomalidomide 4'-PEG2-azide is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing a Pomalidomide-based cereblon ligand and a linker.