PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.
A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V78486 | (S,E)-TCO2-PEG8-acid | (S)-TCO-PEG8-acid is a click chemistry PEG linker with a terminal carboxylic acid (COOH) group. | |
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V82909 | (S,R,S)-AHPC-amido-C7-acid | 2172819-76-8 | (S,R,S)-AHPC-amido-C7-acid contains VHL ligand and PROTAC (PROteolysis TArgeting Chimera) linker for recruitment of E3 ubiquitin ligase. |
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V82905 | (S,R,S)-AHPC-C1-Br | 2379404-33-6 | (S,R,S)-AHPC-C1-Br is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligands based on (S,R,S)-AHPC and 1 linker, which may be utilized to prepare PROTAC molecules. |
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V82855 | (S,R,S)-AHPC-C1-NH2 | 2010986-20-4 | (S,R,S)-AHPC-C1-NH2 is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligands based on (S,R,S)-AHPC and 1 linker, which may be utilized to prepare PROTAC molecules. |
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V82638 | (S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) | 2341796-74-3 | (S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing (S,R ,S)-AHPC VHL ligand and 1 linker. |
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V82708 | (S,R,S)-AHPC-C2-NH2 | 2241643-69-4 | (S,R,S)-AHPC-C2-NH2 is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligands based on (S,R,S)-AHPC and 1 linker, which may be utilized to prepare PROTAC molecules. |
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V82963 | (S,R,S)-AHPC-C2-NH2 dihydrochloride | 2341796-73-2 | (S,R,S)-AHPC-C2-NH2 di-HCl contains the ligand VHL for E3 ubiquitin ligase and the PROTAC (PROteolysis TArgeting Chimera) linker. |
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V82999 | (S,R,S)-AHPC-C3-NH2 hydrochloride (VH032-C3-NH2 hydrochloride) | 2940858-65-9 | (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) HCl is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligand based on VH032 body and 1 linker, which may be utilized to prepare PROTAC molecules. |
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V82627 | (S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) | 2688842-02-4 | (S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VH032-based VHL ligand and 1 linker. |
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V82967 | (S,R,S)-AHPC-C6-NH2 (VH032-C6-NH2) | 2306389-03-5 | (S,R,S)-AHPC-C6-NH2 (VH032-C6-NH2) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligand based on VH032 and 1 linker, which may be utilized to prepare PROTAC molecules. |
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V82717 | (S,R,S)-AHPC-C7-amine (VH032-C7-amine) | 2306389-04-6 | (S,R,S)-AHPC-C7-amine (VH032-C7-amine) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligand based on VH032 body and 1 linker. |
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V82735 | (S,R,S)-AHPC-CO-C9-acid (VH032-NH-CO-C9-acid) | 2172819-78-0 | (S,R,S)-AHPC-CO-C9-acid is a ligand (for E3 ligase)-linker conjugate that attaches to a protein's ligand to form a PROTAC. |
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V83015 | (S,R,S)-AHPC-Me-C10-Br | 2836297-55-1 | (S,R,S)-AHPC-Me-C10-Br is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate. |
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V82949 | (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 | 2409538-69-6 | (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthetic E3 ligase ligand conjugate that combines VHL ligand and linker. |
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V82800 | (S,R,S)-AHPC-Me-decanedioic acid | 2380273-45-8 | (S,R,S)-AHPC-Me-decanedioic acid is a ligand (for E3 ligase)-linker conjugate that may be utilized to prepare PROTAC. |
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V82826 | (S,R,S)-AHPC-PEG1-NH2 (VH032-PEG1-NH2) | 2241641-57-4 | (S,R,S)-AHPC-PEG1-NH2 (VH032-PEG1-NH2) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligand based on VH032 and 1 linker, which may be utilized to prepare PROTAC molecules. |
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V82653 | (S,R,S)-AHPC-PEG1-NH2 dihydrochloride (VH032-PEG1-NH2 dihydrochloride) | 2341796-83-4 | (S,R,S)-AHPC-PEG1-NH2 (VH032-PEG1-NH2) di-HCl contains a VHL ligand for E3 ubiquitin ligase and a PROTAC (PROteolysis TArgeting Chimera) linker. |
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V82667 | (S,R,S)-AHPC-PEG3-propionic acid | 2140807-42-5 | (S,R,S)-AHPC-PEG3-propionic acid is a ligand (for E3 ligase )-linker conjugate containing (S,R,S)-AHPC-based VHL ligand and 3 Polyethylene glycol (PEG) units linker. |
|
V83012 | (S,R,S)-AHPC-PEG5-Boc | 2923734-82-9 | (S,R,S)-AHPC-PEG5-Boc is an E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligands based on (S,R,S)-AHPC and 1 linker. |
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V82920 | (S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH; VHL Ligand-Linker Conjugates 16; E3 Ligase Ligand-Linker Conjugates 58) | 2172820-14-1 | (S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a ligand (for E3 ligase )-linker conjugate containing (S,R,S)-AHPC-based VHL ligand body and 5-unit PEG linker. |
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