PROTAC Linkers

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer.Target protein binders and E3 ligase recruiters, two functional motifs of a PROTAC, are joined by the PROTAC linker.

A PROTAC's linker has a crucial function. The characteristics of the linker (type, length, attachment position) can influence how ligase is formed. The PROTAC:target ternary complex affects the target protein's effective ubiquitination and eventual destruction. According to reports, the ideal linker lengths for PROTACs range from 12 to over 20 carbons. PEGs, alkyl chains, and alkyl ether are the most often employed linkers in the creation of PROTACs.

PROTAC Linkers related products

Cat No.	Product Name	CAS No.	Product Description
V112612	(4-(((tert-Butoxycarbonyl)amino)methyl)phenyl)boronic acid	489446-42-6	(4-((tert-Butoxycarbonyl)amino)methyl)phenyl)boronic acid is a PROTAC linker that can be used to synthesize PROTAC molecules.
V104448	(4-(1H-1,2,3-Triazol-4-yl)phenyl)methanol	2149801-20-5	(4-(1H-1,2,3-triazol-4-yl)phenyl)methanol is a PROTAC Linker.
V112746	(4-(3-Bromopropoxy)phenyl)boronic acid	957034-33-2	(4-(3-bromopropoxy)phenyl)boronic acid is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113660	(4-(3-Methoxy-3-oxopropyl)phenyl)boronic acid	850568-44-4	(4-(3-methoxy-3-oxopropyl)phenyl)boronic acid is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113535	(4-Bromobutoxy)benzene	1200-03-9	(4-Bromobutoxy)benzene is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112884	(4-Bromobutyl)boronic acid	61632-72-2	(4-Bromobutyl)boronic acid is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113681	(4-Ethynylphenyl)methanol	10602-04-7	(4-Ethynylphenyl)methanol is a PROTAC linker that can be used to synthesize PROTAC molecules.
V112624	(6R,8S,10R,11S,13S,14R)-17-(2-Acetoxyacetyl)-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate	91898-32-7	(6R,8S,10R,11S,13S,14R)-17-(2-acetoxyacetyl)-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecylhydro-3H-cyclopenta[a]phenanthrene-17-ylpropionate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V114106	(9H-Fluoren-9-yl)methyl (2-bromoethyl)carbamate	340187-12-4	(9H-fluorene-9-yl)methyl(2-bromoethyl)carbamate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113521	(9H-Fluoren-9-yl)methyl (3-aminopropyl)carbamate hydrochloride	210767-37-6	(9H-fluorene-9-yl)methyl(3-aminopropyl)carbamate hydrochloride is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113532	(9H-Fluoren-9-yl)methyl (4-aminobutyl)carbamate	117048-49-4	(9H-fluorene-9-yl)methyl(4-aminobutyl)carbamate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113971	(9H-Fluoren-9-yl)methyl (4-aminobutyl)carbamate hydrochloride	321660-77-9	(9H-fluorene-9-yl)methyl(4-aminobutyl)carbamate hydrochloride is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113825	(9H-fluoren-9-yl)methyl (5-aminopentyl)carbamate hydrochloride	177333-17-4	(9H-fluorene-9-yl)methyl(5-aminopentyl)carbamate hydrochloride is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113801	(9H-Fluoren-9-yl)methyl (5-hydroxypentyl)carbamate	209115-33-3	(9H-fluorene-9-yl)methyl(5-hydroxypentyl)carbamate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V114069	(9H-Fluoren-9-yl)methyl (6-hydroxyhexyl)carbamate	127903-20-2	(9H-fluorene-9-yl)methyl(6-hydroxyhexyl)carbamate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113911	(9H-Fluoren-9-yl)methyl tert-butyl ethane-1,2-diyldicarbamate	166410-28-2	(9H-fluorene-9-yl)methyl tert-butylethane-1,2-dimethyldicarbamate is a PROTAC linker that can be used to synthesize PROTAC molecules.
V82861	(E)-TCO-PEG4-NHS ester	1621096-79-4	(E)-TCO-PEG4-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V113941	(E)-tert-Butyldimethyl((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)allyl)oxy)silane	114653-19-9	(E)-tert-butyldimethyl((3-(4,4,5,5-tetramethyl-1,3,2-dioxoboran-2-yl)allyl)oxy)silane is a PROTAC linker that can be used to synthesize PROTAC molecules.
V113994	(E)-tert-Butyldimethyl((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-1-yl)oxy)silane	480425-30-7	(E)-tert-butyldimethyl((4-(4,4,5,5-tetramethyl-1,3,2-dioxoboran-2-yl)but-3-en-1-yl)oxy)silane is a PROTAC linker that can be used to synthesize PROTAC molecules.
V104323	(R)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline		(R)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline is the linker of NX-2127.