Molecular Glues

A component of molecular glues is a protein degradation agent based on the ubiquitin-proteasome pathway. Small molecule substances known as "molecular glues" have the ability to stimulate or maintain protein binding. Molecular glue can cause another protein to undergo ubiquitin modification and destruction through the proteasome pathway, which is analogous to PROTAC, if one of the proteins is an ubiquitin ligase. However, in a later classification, these compounds are categorized as functional molecules that act as E3 ligase ligands. Thalidomide, lenalidomide, and pomalidomide, as well as the later-reported CC-90009 and CC-92480, are examples of older medications that fall into this group.

Molecular Glues related products

Cat No.	Product Name	CAS No.	Product Description
V104597	(S)-ACE-OH		(S)-ACE-OH is a molecular glue with anticancer activity.
V82621	2-(2,6-Dioxopiperidin-3-yl)phthalimidine-C5-Br	2411022-24-5	2-(2,6-Dioxopiperidin-3-yl)phthalimidine-C5-Br is a ligand (for E3 ligase)-linker conjugate used in the preparation /synthesis of PROTAC.
V85957	Acetyl-cyclosporin A aldehyde	121584-52-9
V87964	CDO1 degrader-1		CDO1 degrader-1 (compound 8) is a molecular glue degrader targeting cysteine dioxygenase (CDO1).
V105164	ChREBPα/14-3-3 regulator-1		ChREBPα/14-3-3 modulator-1 (Compound 43) is a selective molecular glue that stabilizes the interaction between carbohydrate response element binding protein (ChREBP) and 14-3-3 proteins with an EC50 of 3.8 μM.
V105151	CQ627		CQ627 is a molecular glue that targets RIOK2 for degradation.
V87956	DS17		DS17 is a molecular glue that acts as an effective degrader of cyclin K with an EC50 of 13 nM.
V3568	E7820	289483-69-8	E7820 (E-7820) is a novel and potent angiogenesis inhibitor and α2 integrin inhibitor with anticancer activity.
V103999	EM12-FS	2839138-44-0	EM12-FS is a cereblon (CRBN) ligand that binds to CRBN at the His353 site and is a molecular glue degrader of NTAQ1.
V82620	endo-BCN-PEG2-NH2	1263166-93-3	endo-BCN-PEG2-NH2 is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V87960	ER degrader 9	3023359-75-0	ER degrader 9 (compound 1) is a bifunctional molecule and a potent estrogen receptor (ER) degrader with a DC50 of ≤10 nM in MCF-7 cells.
V104608	FIZ1 degrader 1	1957235-62-9	FIZ1 degrader 1 (compound 1) is an IMiD-based molecular glue degrader targeting FIZ1.
V104856	GR–14-3-3 stabilizer-1	271798-59-5	GR-14-3-3 stabilizer-1 (compound 10) is a molecular glue stabilizer that can be used to prepare molecular glue targeting glucocorticoid (GR) and blocking the interaction between GR and 14-3-3.
V87958	GSPT1 degrader-4	3034764-32-1	GSPT1 degrader-4 (3) is a molecular glue for GSPT1 (DC50 of 25.4 nM) with an IC50 value of 39 nM in CAL51 cells.
V87963	GSPT1 degrader-5	3034764-38-7	GSPT1 degrader-5 (4) is a molecular glue for GSPT1 (DC50 of 144 nM).
V87959	GSPT1 degrader-6	3034764-41-2	GSPT1 degrader-6 (8) is a molecular glue for GSPT1 (DC50 of 13 nM).
V87966	HbF inducer 2	2654011-51-3	HbF inducer 3 (Compound dWIZ-2) is an orally available molecular glue that degrades WIZ transcription factor (DC50=13 nM in primary human erythroid progenitor cells) and induces fetal hemoglobin (HbF) expression (EC50=100 nM).
V88888	HuR degrader 2		HuR degrader 2 (Compound 3) is a molecular glue that can target and degrade the RNA binding protein Hu antigen R (HuR), and can degrade 30% of HuR at 0.1 μM.
V105048	IPS-06061		IPS-06061 is an oral molecular glue that forms a ternary complex of CRBN-KRASG12D-IPS06061 and can degrade KRAS G12D with a DC50 of less than 500 nM.
V87961	JWJ-01-306		JWJ-01-306 is a molecular glue targeting the C2H2 zinc finger transcription factor ZBTB11.