Ligands for Target Protein for PROTAC

Target proteins are often proteins that may contribute significantly to the development of illnesses through overexpression or accumulation. Numerous PROTACs have been created to destroy kinases (like MEK, KRAS, CDK, and Bcr/Abl), transcription factors (like p53, STAT, RAR, ER, and AR), epigenetic tools (like HDAC and BET bromodomain), and E3 ligases themselves (like MDM2).

Target proteins are often proteins that may contribute significantly to the progression of illnesses through overexpression or accumulation. Numerous PROTACs have been created to destroy E3 ligases including MDM2, MEK, KRAS, CDK, and Bcr/Abl, transcription factors like p53, STAT, RAR, ER, and AR, epigenetic tools like HDAC, and BET bromodomain.

Ligands for Target Protein for PROTAC related products

Cat No.	Product Name	CAS No.	Product Description
V102517	(R)-I-BET762 carboxylic acid	1786401-70-4	(R)-I-BET762 carboxylic acid is the R isomer of I-BET762 carboxylic acid.
V105466	(Rac)-BMS-1	1675201-97-4	(Rac)-BMS-1 is the racemic form of BMS-1.
V99927	(S)-SKBG-1	2955618-24-1	(S)-SKBG-1 is the PROTAC target protein ligand.
V97356	5-Br-4-Cl-Pyrrolo-pyroxypyridine	2914920-46-8	5-Br-4-Cl-pyrrolopyridine is a PROTAC target protein ligand (target protein ligand of PROTACs).
V84444	7α,25-Dihydroxycholesterol intermediate-1	1326612-12-7
V77307	Abemaciclib metabolite M18-d8 (LSN3106729-d8)		Abemaciclib metabolite M18-d8 is the deuterium labelled form of Abemaciclib metabolite M18.
V87939	Aberrant tau ligand 1	1892461-96-9	Aberrant tau ligand 1 is a ligand for abnormal tau protein.
V94376	AK-068	2982851-09-0	AK-068 is a STAT6 ligand with a Ki value of 6 nM and is at least 85-fold more selective than STAT5.
V94363	AK-068-OH	2982851-61-4	AK-068-OH (compound 49) is an activity control of the PROTAC target protein ligand.
V87279	AKR1C3-IN-13		AKR1C3-IN-13 (Compound 4) is an AKR1C3 inhibitor.
V104711	ALK protein ligand-1	2764870-80-4	ALK protein ligand-1 (Compound A1) is a ligand of anaplastic lymphoma kinase (ALK) and a PROTAC target protein ligand (Ligands for Target Protein for PROTACs) that has an inhibitory effect on ALK.
V94559	Alkyne-P60		Alkyne-P60 is a potent peptide inhibitor of Foxp3 15 .
V82617	Amine-PEG3-Desthiobiotin	2237234-71-6	Amine-PEG3-Desthiobiotin is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82612	Amino-PEG23-amine	2673284-93-8	Amino-PEG23-amine is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V104278	AR ligand-29	88378-55-6	AR ligand-29 is the target protein ligand of PROTAC VinclozolinM2-2204 and can be used in cancer research.
V104279	AR ligand-30	2505498-73-5	AR ligand-30 is the target protein ligand of PROTAC Bavdegalutamide and can be used for prostate cancer research.
V104902	AR ligand-31		AR ligand-31 is a PROTAC target protein ligand that can be used to synthesize PROTAC AR Degrader-5.
V104960	AR ligand-32	2505498-74-6	AR ligand-32 is the target protein ligand used to synthesize PROTAC AR Degrader-7.
V104982	AR ligand-33		AR ligand-33 is a ligand for androgen receptor and can be used as a target protein ligand for PROTAC AR Degrader-8 synthesis.
V104447	AR ligand-37		AR ligand-37 is a PROTAC target protein ligand that can be used to synthesize BMS-986365.