Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V97355	(3S)Lenalidomide-5-Br	2829898-76-0	(3S)Lenalidomide-5-Br is a ligand for E3 ubiquitinases.
V113047	(R)-Desamino lenalidomide-5-Br	2243825-20-7	(R)-Deaminolenalidomide-5-Br is an E3 ubiquitin ligand that binds to cereblon (CRBN) protein and is used to recruit cereblon protein.
V112983	(R,R,R)-AHPC hydrochloride		(R,R,R)-AHPC hydrochloride is an E3 ubiquitin ligand VHL used to recruit VHL proteins.
V113037	(R,R,S)-AHPC	2764746-08-7	(R,R,S)-AHPC ((R,R,S)-VH032-NH2) is a VHL ligand based on (S,R,S)-AHPC that recruits the von Hippel-Lindau (VHL) protein.
V120143	(R,S,R)-AHPC-Me-Ac		(R,S,R)-AHPC-Me-Ac is an E3 ligase ligand that can be used to synthesize PROTAC SHP2 protein degrader-2.
V112927	(R,S,R)-AHPC-NHBoc	1799506-31-2	(R,S,R)-AHPC-NHBoc is an E3 ubiquitin ligand and also a VHL ligand used to recruit VHL proteins.
V120123	(R,S,S)-VH032-Me TFA	2451573-93-4	(R,S,S)-VH032-Me TFA is an E3 ligase ligand that can be used to synthesize dTAGV-1 hydrochloride.
V111867	(rel)-Nutlin carboxylic acid	2760669-71-2	(rel)-Nutlin carboxylic acid is an MDM2 ligand based on Nutlin 3.
V104992	(S)-(S,R,S,R)-AHPC-Me-N3	2958620-43-2	(S)-(S,R,S,R)-AHPC-Me-N3 is the E3 ligase ligand of PROTAC SMARCA2 degrader-32 and can be used for the synthesis of PROTAC.
V97123	(S)-Deoxy-thalidomide	107657-57-8	(S)-Deoxythalidomide is an E3 ubiquitin ligase ligand.
V104287	(S)-Deoxy-thalidomide-Br		(S)-Deoxythalidomide-Br is a ligand for the E3 ligase and was used to synthesize PROTAC FHD-609.
V83803	(S)-PROTAC PTK6 ligand-1-(2S,4R)-O-CH2-O-hygric acid
V83735	(S)-PROTAC PTK6 ligand-O-4,4-dimethylpiperidine-Boc
V83726	(S)-PROTAC PTK6 ligand-O-C2-O-piperidine-Boc
V112556	(S)-Thalidomide-5-OH	172333-29-8	(S)-Thalidomide-5-OH is the E3 ubiquitin ligand for cereblon (CRBN) protein, used to recruit cereblon protein.
V100321	(S,R,R)-VH032	2489876-59-5	(S,R,R)-VH032 (compound V3) is a VHL ligand that can be used to synthesize PROTAC NCOA4 degrader-1.
V113722	(S,R,R)-VH032 hydrochloride	2761478-98-0	(S,R,R)-VH032 hydrochloride is a VH032-based VHL ligand that recruits the von Hippel-Lindau (VHL) protein.
V113717	(S,R,S)-AHPC 2-OH hydrochloride	2244684-41-9	(S,R,S)-AHPC 2-OH hydrochloride is an E3 ubiquitin ligand that can be used to recruit VHL proteins.
V85210	(S,R,S)-AHPC dihydrochloride (VH032-NH2 dihydrochloride; VHL ligand 1 dihydrochloride)	2137142-47-1
V89049	(S,R,S)-AHPC(Me)-amido-C2-acid	2365173-01-7	(S,R,S)-AHPC(Me)-amido-C2-acid is a VHL (E3 ligase) ligand that can be used to synthesize PROTACs, such as PROTAC STING Degrader-2.