Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V112793	Desamino lenalidomide-CH2NH2 hydrochloride	2248702-12-5	Deaminolenalidomide-CH2NH2 hydrochloride is the E3 ubiquitin ligand of cereblon (CRBN) and is used to recruit cereblon protein.
V113362	Desamino lenalidomide-COOH	2287259-68-9	Deaminolenalidomide-COOH is an E3 ubiquitin ligand that binds to cereblon (CRBN) protein and is used to recruit cereblon protein.
V112850	Desamino lenalidomide-cyano	2639386-82-4	Deaminolenalidomide-cyano is an E3 ubiquitin ligand that binds to cereblon (CRBN) protein and is used to recruit cereblon protein.
V112879	Desamino lenalidomide-ethynyl	1416990-26-5	Deaminolenalidomide ethynyl is an E3 ubiquitin ligand that binds to cereblon (CRBN) protein and is used to recruit cereblon protein.
V113676	Desamino lenalidomide-NO2	1198787-23-3	Deaminolenalidomide-NO2 is an E3 ubiquitin ligand that binds to cereblon (CRBN) and recruits the cereblon protein.
V112875	Desamino lenalidomide-pinacolborane	2291363-98-7	Deaminolenalidomide-pinacolborane is an E3 ubiquitin ligand for cereblon (CRBN) and can recruit cereblon proteins.
V113661	Desamino lenalidomide[3,4-g]piperidine	2616539-63-8	Deaminolenalidomide [3,4-g]piperidine is an E3 ubiquitin ligand for cereblon (CRBN) protein and is used to recruit cereblon protein.
V116585	Dihydrouracil-Ph-2-Me-piperidine	3027839-56-8	Dihydrouracil-Ph-2-Me-piperidine is an E3 ligand.
V93954	DYR684e	2377851-46-0	DYR684e is a ligand for E3 ligase and can be used to synthesize the PROTAC degrader DYR684.
V82548	E3 ligase Ligand 13	2701565-75-3	E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand.
V87926	E3 ligase Ligand 25	2633633-39-1	E3 ligase Ligand 25 (part of Compd 1) is a ligand of E3 ligase used to synthesize SOS1 PROTAC degrader.
V87933	E3 ligase Ligand 26	2911613-35-7	E3 ligase Ligand 26 (part of Compd 10) is a ligand of E3 ligase used to synthesize SOS1 PROTAC degrader.
V87927	E3 ligase Ligand 27	3034204-25-3	E3 ligase Ligand 27 (part of 15) is a ligand for E3 ligase and can be used to synthesize PROTAC BcI-2/BcI-xI Degrader-1.
V99946	E3 ligase Ligand 29	2154341-52-1	E3 ligase ligand 29 is a ligand for E3 ubiquitin ligase.
V3590	E3 Ligase Ligand 3	1061605-21-7	E3 ligase Ligand 3, a carboxylic acid-functionalized analog of thalidomide, is a CRBN ligand for E3 Ligase used in PROTAC technology.
V99962	E3 ligase Ligand 30	2725913-42-6	E3 ligase ligand 30 is a ligand for E3 ubiquitin ligase.
V97297	E3 ligase Ligand 31	2357114-13-5	E3 ligase ligand 31 is a ligand for E3 ubiquitinase.
V97494	E3 ligase Ligand 32	2300099-98-1	E3 ligase ligand 32 (the first product in sample 52) is a ligand for the E3 ubiquitin ligase.
V97224	E3 ligase Ligand 33	3023410-43-4	E3 ligase ligand 33 (56-9B) is an E3 ubiquitin ligase ligand.
V93170	E3 ligase Ligand 34	2931870-73-2	E3 ligase ligand 34 is the E3 ligase ligand portion of PROTAC SMARCA2/4-degrader-35 and can be used in the synthesis of PROTAC.