Ligands for E3 Ligase

A PROTAC (Proteolysis Targeting Chimeric Molecule) is a protein degrader comprised of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand for target protein (target binder).The transfer of ubiquitin and degradation of the targeted protein will occur as a result of the connection between an E3 ligase and a target protein brought on by a PROTAC.

E3 ligases determine the specificity of the proteins by catalyzing the transfer of ubiquitin to the desired proteins. Cells have hundreds of E3 ligases, but only a small number of them have been successfully exploited in PROTACs, including VHL (the tumor suppressor protein for von Hippel-Lindau disease), CRBN (Cereblon), MDM2 (the mouse double minute 2 homologue), and IAP (inhibitor of apoptosis).

Ligands for E3 Ligase related products

Cat No.	Product Name	CAS No.	Product Description
V84437	SOS1 Ligand intermediate-1	2380273-21-0
V84448	SOS1 Ligand intermediate-2	2380273-24-3
V82582	t-Butyl acetate-PEG3-CH2COOH	1442466-57-0	t-Butyl acetate-PEG3-CH2COOH is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V84545	Thalidomide 4'-ether-PEG1-azide	2758432-02-7
V82551	Thalidomide-4-NH-PEG1-COOH TFA	2140807-20-9	Thalidomide-4-NH-PEG1-COOH TFA is a conjugate of E3 ligase ligand and linker consisting of Thalidomide and NH-PEG3-NH-Boc.
V82574	Thalidomide-4-NH-PEG1-NH2 TFA	2490499-21-1	Thalidomide-4-NH-PEG1-NH2 TFA is an E3 ligase (e.g. CRBN) ligand-linker conjugate consisting of Thalidomide nd NH-PEG3-NH-Boc.
V82576	Thalidomide-4-NH-PEG2-COO(t-Bu)	2140807-16-3	Thalidomide-4-NH-PEG2-COO(t-Bu) is a t-Bu modified Thalidomide, which could be utilized as Cereblon ligand to recruit CRBN protein.
V76438	Thalidomide-4-O-C10-NH2 hydrochloride		Thalidomide-4-O-C10-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V76437	Thalidomide-4-O-C11-NH2 hydrochloride		Thalidomide-4-O-C11-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V76436	Thalidomide-4-O-C12-NH2 hydrochloride		Thalidomide-4-O-C12-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V81567	Thalidomide-4-O-C13-NH2 hydrochloride		Thalidomide-4-O-C13-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V76435	Thalidomide-4-O-C14-NH2 hydrochloride		Thalidomide-4-O-C14-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V76434	Thalidomide-4-O-C7-NH2 hydrochloride		Thalidomide-4-O-C7-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN proteins.
V81568	Thalidomide-4-O-C9-NH2 hydrochloride		Thalidomide-4-O-C9-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.
V112794	Thalidomide-4-OH-(S)-CH3	1957235-70-9	Thalidomide-4-OH-(S)-CH3 is the E3 ubiquitin ligand for cereblon (CRBN) protein, used to recruit cereblon protein.
V113820	Thalidomide-5-F-6-I	3037693-01-6	Thalidomide-5-F-6-I is an E3 ubiquitin ligand that binds to cereblon (CRBN) and recruits the cereblon protein.
V113777	Thalidomide-5-methanol	2825006-38-8	Thalidomide-5-methanol is the E3 ubiquitin ligand for cereblon (CRBN) and is used to recruit cereblon proteins.
V82549	Thalidomide-5-methyl	40313-92-6	Thalidomide-5-methyl is a Thalidomide-based CRBN ligand used for CRBN protein recruitment.
V82522	Thalidomide-5-NH-CH2-COO(t-Bu)	2412056-28-9	Thalidomide-5-NH-CH2-COO(t-Bu) is a t-Bu modified Thalidomide , which could be utilized as Cereblon ligand to recruit CRBN protein.
V81569	Thalidomide-5-NH-PEG5-NH2 hydrochloride		Thalidomide-5-NH-PEG5-NH2 HCl is a Thalidomide-based cereblon (E3 ligase) ligand that recruits CRBN protein.