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E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Structure Cat No. Product Name CAS No. Product Description
(3S)Lenalidomide-5-methylpiperazine benzenesulfonate V113841 (3S)Lenalidomide-5-methylpiperazine benzenesulfonate 2229714-16-1 (3S) Lenalidomide-5-methylpiperazine benzenesulfonate is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
(3S)Lenalidomide-5-Pip-C-Pip-2C-Pip V97301 (3S)Lenalidomide-5-Pip-C-Pip-2C-Pip (3S)Lenalidomide-5-Pip-C-Pip-2C-Pip is an E3 ligase ligand-adapter conjugate.
(3S)Lenalidomide-piperazine-C-piperidine V121559 (3S)Lenalidomide-piperazine-C-piperidine 2520107-24-6 (3S)Lenalidomide-piperazine-C-piperidine is an E3 ubiquitination enzyme ligand + linker conjugate (E3 ligand ligand-linker conjugate).
(4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 V121603 (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 2977227-58-8 (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 is a synthetic E3 ligand-linker conjugate that contains an MDM2 ligand based on (4R,5S)-Nutlin carboxylic acid and a linker used in the PROTAC technique.
(4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3 V121604 (4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3 3035510-04-1 (4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3 is a synthetic E3 ligand-linker conjugate that contains an MDM2 ligand based on (4R,5S)-Nutlin carboxylic acid and a linker used in the PROTAC technique.
(E)-JP-2-196 TFA V121773 (E)-JP-2-196 TFA 3065021-33-9 (E)-JP-2-196 TFA is a molecular gel linker that can bind to E3 ubiquitin ligases (RNF126, LRSAM1, RNF40, MID2, and RNF14) in vitro.
(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 V104284 (R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 is the E3 ubiquitin ligase ligand and linker of PROTAC (R)-NX-2127, which can be used in cancer research.
(R,S,R)-AHPC-PEG2-C2-boc V97248 (R,S,R)-AHPC-PEG2-C2-boc (R,S,R)-AHPC-PEG2-C2-boc is an E3 ubiquitinase ligand + linker conjugate.
(R,S,S)-VH032-Me-glycine V121989 (R,S,S)-VH032-Me-glycine 2407458-67-5 (R,S,S)-VH032-Me-glycine is an E3 ligase ligand-linker conjugate.
(R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid V121990 (R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid (R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid is an E3 ligase ligand-linker conjugate composed of N-Boc-7-aminoheptanoic acid and the corresponding linker.
(R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid TFA V120244 (R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid TFA (R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid TFA is a conjugate composed of an E3 ubiquitin ligase ligand and a linker.
(R,S,S)-VH032-PEG5-N3 V112865 (R,S,S)-VH032-PEG5-N3 2766352-74-1 (R,S,S)-VH032-PEG5-N3 is an E3 ligand-linker conjugate consisting of a VHL ligand based on VH032 and a 5-unit PEG linker.
(S)-(S,R,S,R)-AHPC-Me-N3-C6-COOH V122067 (S)-(S,R,S,R)-AHPC-Me-N3-C6-COOH (S)-(S,R,S,R)-AHPC-Me-N3-C6-COOH is an E3 ligase ligand-linker conjugate containing an E3 ligase ligand and a PROTAC linker.
(S)-Deoxy-thalidomide-(R)-pyrrolidine-3-carbaldehyde V113734 (S)-Deoxy-thalidomide-(R)-pyrrolidine-3-carbaldehyde 2952806-82-3 (S)-Deoxythalidomide-(R)-pyrrolidine-3-carboxaldehyde is an E3 ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
(S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-C-Pip V104289 (S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-C-Pip (S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-C-Pip is an E3 ubiquitin ligase ligand + linker conjugate used in the synthesis of PROTAC FHD-609.
(S)-Deoxy-thalidomide-6-F-5-piperazine benzenesulfonate V113725 (S)-Deoxy-thalidomide-6-F-5-piperazine benzenesulfonate 2504914-78-5 (S)-Deoxythalidomide-6-F-5-piperazine benzenesulfonate is an E3 ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
(S)-Deoxy-thalidomide-Pip-3-hydroxypropanoic acid V113095 (S)-Deoxy-thalidomide-Pip-3-hydroxypropanoic acid 3032320-78-5 (S)-Deoxythalidomide-Pip-3-hydroxypropionic acid is an E3 ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
(S)-Deoxy-thalidomide-Pip-3-hydroxypropanoic acid hydrochloride V112759 (S)-Deoxy-thalidomide-Pip-3-hydroxypropanoic acid hydrochloride 3032320-79-6 (S)-Deoxythalidomide-piperidine-3-hydroxypropionate salt is an E3 ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
(S)-Desamino lenalidomide-2,7-diazaspiro[3.5]nonane V112778 (S)-Desamino lenalidomide-2,7-diazaspiro[3.5]nonane (S)-Deaminated lenalidomide-2,7-diazaspiro[3.5]nonane is an E3 ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
(S)-E3 Ligase Ligand-linker Conjugate 140 V122165 (S)-E3 Ligase Ligand-linker Conjugate 140 (S)-E3 Ligase Ligand-linker Conjugate 140 is an E3 ligase ligand-linker conjugate.
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