E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Cat No.	Product Name	CAS No.	Product Description
V113841	(3S)Lenalidomide-5-methylpiperazine benzenesulfonate	2229714-16-1	(3S) Lenalidomide-5-methylpiperazine benzenesulfonate is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
V97301	(3S)Lenalidomide-5-Pip-C-Pip-2C-Pip		(3S)Lenalidomide-5-Pip-C-Pip-2C-Pip is an E3 ligase ligand-adapter conjugate.
V104284	(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2		(R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 is the E3 ubiquitin ligase ligand and linker of PROTAC (R)-NX-2127, which can be used in cancer research.
V97248	(R,S,R)-AHPC-PEG2-C2-boc		(R,S,R)-AHPC-PEG2-C2-boc is an E3 ubiquitinase ligand + linker conjugate.
V120244	(R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid TFA		(R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid TFA is a conjugate composed of an E3 ubiquitin ligase ligand and a linker.
V112865	(R,S,S)-VH032-PEG5-N3	2766352-74-1	(R,S,S)-VH032-PEG5-N3 is an E3 ligand-linker conjugate consisting of a VHL ligand based on VH032 and a 5-unit PEG linker.
V113734	(S)-Deoxy-thalidomide-(R)-pyrrolidine-3-carbaldehyde	2952806-82-3	(S)-Deoxythalidomide-(R)-pyrrolidine-3-carboxaldehyde is an E3 ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
V104289	(S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-C-Pip		(S)-Deoxy-thalidomide-2,7-diazaspiro[3.5]nonane-C-Pip is an E3 ubiquitin ligase ligand + linker conjugate used in the synthesis of PROTAC FHD-609.
V113725	(S)-Deoxy-thalidomide-6-F-5-piperazine benzenesulfonate	2504914-78-5	(S)-Deoxythalidomide-6-F-5-piperazine benzenesulfonate is an E3 ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
V113095	(S)-Deoxy-thalidomide-Pip-3-hydroxypropanoic acid	3032320-78-5	(S)-Deoxythalidomide-Pip-3-hydroxypropionic acid is an E3 ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
V112759	(S)-Deoxy-thalidomide-Pip-3-hydroxypropanoic acid hydrochloride	3032320-79-6	(S)-Deoxythalidomide-piperidine-3-hydroxypropionate salt is an E3 ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
V112778	(S)-Desamino lenalidomide-2,7-diazaspiro[3.5]nonane		(S)-Deaminated lenalidomide-2,7-diazaspiro[3.5]nonane is an E3 ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
V113858	(S)-Glutarimide-amide-Py-piperidine-CHO	2649400-06-4	(S)-Glutamylimide-amide-pyridine-piperidine-CHO is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
V117505	(S)-Phthalimidinoglutarimide-6-piperazine	2986073-45-2	(S)-Phenylamidoglutamyl-6-piperazine is the (S)-configuration of phthalimidoglutamyl-6-piperazine.
V112916	(S)-Thalidomide-5-fluoro-6-piperazin besylate	2937062-27-4	(S)-Thalidomide-5-fluoro-6-piperazine benzenesulfonate is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
V113574	(S)-Thalidomide-azetidine-O-Pip	2782051-26-5	(S)-Thalidomide-azacyclobutane-O-Pip is an E3 ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
V98703	(S)-Thalidomide-NH-cyclohexane-NH-Ph-NH2		(S)-thalidomide-NH-cyclohexane-NH-Ph-NH2 (compound C63) is a PROTAC E3 ligase + linker, which contains a thalidomide-based cereblon ligand and a linker and can be used to synthesize PROTACs.
V113612	(S)-Thalidomide-piperazin besylate	2937046-84-7	(S)-Thalidomide-piperazine benzenesulfonate is an E3 ligand-linker conjugate containing a CRBN-based ligand and a linker, which can be used to synthesize PROTAC.
V104324	(S)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2		(S)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 is a conjugate of an E3 ubiquitin ligase ligand and the NX-2127 linker.
V99665	(S,R,R)-VH032-CO-C3-CONH-C2-PEG3-OH		(S,R,R)-VH032-CO-C3-CONH-C2-PEG3-OH is a conjugate of the E3 ligase ligand and linker of PROTAC NCOA4 Degrader-1 (E3 ligase ligand-linker conjugate).