E3 Ligase Ligand-Linker Conjugates

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker.These conjugates can be used to create PROTACs that target proteins for ubiquitination and destruction after being coupled to the ligand for the target protein (for example, JQ1 for the BRD4 protein or Molibresib for the BET protein). Currently, a number of PROTACs that specifically target BET, the estrogen receptor (ER), the androgen receptor, etc. have been identified to demonstrate good biological activity.

E3 Ligase Ligand-Linker Conjugates related products

Cat No.	Product Name	CAS No.	Product Description
V82409	N-Ethylpropionamide-PEG1-Br	1539080-27-7	N-Ethylpropionamide-PEG1-Br is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V104986	N-Me-Thalidomide-NH-C6-NH2	2375536-48-2	N-Me-Thalidomide-NH-C6-NH2 is an E3 ligase ligand-adapter conjugate.
V82342	Narlumosbart	2646587-68-8	Narlumosbart (JMT103) is an IgG4κ antibody targeting receptor agonist/activator of nuclear factor-κB ligand (RANKL).
V82373	NH2-PEG3 hydrochloride	92505-84-5	NH2-PEG3 HCl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82507	NH2-PEG5-C1-Boc	2231845-67-1	NH2-PEG5-C1-Boc is a PROTAC (PROteolysis TArgeting Chimera) linker of the PEG category, may be utilized to prepare PROTAC protein degraders.
V76688	Nutlin-C1-amido-PEG4-C2-N3 (MDM2 Ligand-Linker Conjugates 1; E3 ligase Ligand-Linker Conjugates 48)		Nutlin-C1-amido-PEG4-C2-N3 is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing a Nutlin 3-based MDM2 ligand and a 4-unit PEG linker.
V104645	OICR-8268-acrylic acid-amino-PEG9-amine		OICR-8268-acrylic acid-amino-PEG9-amine is an E3 ligase ligand-linker complex.
V104895	OTs-PEG3-NHCO-Thalidomide	2716123-18-9	OTs-PEG3-NHCO-Thalidomide is a linker of ubiquitin E3 ligase and PROTAC α-synuclein degrader 6 for neurodegenerative disease research.
V104277	p62-ZZ Ligand-Linker Conjugate 1	2410081-73-9	p62-ZZ ligand-adaptor conjugate 1 is a p62-ZZ domain ligand-adaptor conjugate.
V82473	PCDBCO-PEG4-NHS ester	2055025-02-8	PC DBCO-PEG4-NHS ester is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82370	PEG2-Cl	78925-46-9	PEG2-Cl is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82498	PEG2-ethyl acetate	154773-33-8	PEG2-ethyl acetate is a PROTAC (PROteolysis TArgeting Chimera) linker of the Polyethylene glycol (PEG) category, may be utilized to prepare PROTAC protein degraders.
V82493	Phthalimide-PEG3-C2-OTs	382162-12-1	Phthalimide-PEG3-C2-OTs (Compound 5) is a PROTAC (PROteolysis TArgeting Chimera) linker and belongs to the PEG (Polyethylene glycol) class.
V94657	Piperidin-4-amine-C5-O-C1-Thalidomide	3038591-71-5	Piperidin-4-amine-C5-O-C1-thalidomide (Compound D4) is an E3 ligase ligand-linker conjugate that can be used to synthesize PRPTAC.
V51728	Pom-8PEG	2488761-03-9	Pom-8PEG, a ligand (for E3 ligase)-linker conjugate, contains a cereblon (CRBN) ligand for E3 ubiquitin ligase and an 8-unit PEG linker.
V84833	Pomalidomide 4'-alkylC2-azide	2296708-61-5
V84678	Pomalidomide 4'-alkylC3-acid	2225940-47-4
V84836	Pomalidomide 4'-alkylC3-azide	2357108-05-3
V84641	Pomalidomide 4'-alkylC4-acid	2225940-48-5
V51305	Pomalidomide 4'-PEG3-azide	2271036-46-3	Pomalidomide 4'-PEG3-azide is a synthetic ?E3 ligase ligand-linker conjugate, containing Pomalidomide-based cereblon ligand and 1 linker, which can be used for the synthesis of iRucaparib-TP3.