|
V52787
|
Carbazole-d8 (咔唑-d8) |
38537-24-5 |
|
|
V0725
|
Telaprevir ( LY-570310; VX950; MP-424) |
402957-28-2 |
Telaprevir (also known as LY570310; VX-950; MP424; trade names: Incivek; Incivo), a marketed medication for HCV treatment, is a selective, and reversible peptidomimetic inhibitor of HCV NS3-4A serine protease with an IC50 of 0.35 μM. |
|
V35046
|
Ditiocarb (Diethyldithiocarbamic acid) |
147-84-2 |
|
|
V51454
|
KRA-533 |
10161-87-2 |
KRA-533 is a selective KRAS agonist. |
|
V0611
|
AZD3463 |
1356962-20-3 |
AZD-3463 (AZD3463) is a novel, potent and selective ALK/IGF1R inhibitor with potential anticancer activity. |
|
V0630
|
Pexidartinib (PLX3397; Turalio; CML261; FP113) |
1029044-16-3 |
Pexidartinib (formerly PLX-3397; CML-261;FP-113; trade name Turalio) is an orally bioavailable and multi-targeted RTK (receptor tyrosine kinase) inhibitor of CSF-1R, Kit, and Flt3 with potential antineoplastic activity. |
|
V0633
|
GW2580 (SC203877) |
870483-87-7 |
GW2580 (also known as SC-203877)is a novel, potent, selective, and orally bioavailable c-Fms kinaseCSF-1R inhibitor with potential antineoplastic activity. |
|
V0572
|
Imatinib Mesylate (STI571; Gleevec; Glivec) |
220127-57-1 |
Imatinib Mesylate (also known as STI571 mesylate; trade names: Gleevec or Glivec), the mesylate salt of imatinib, is an orally bioavailable,potent,multi-kinase inhibitor of v-Abl, c-Kit and PDGFR with potential antitumor activity. |
|
V0493
|
Foretinib (GSK-1363089; XL-880; EXEL2880; GSK-089) |
849217-64-7 |
Foretinib (also known as GSK1363089; XL880; EXEL-2880; GSK089) is a novel, potent, ATP-competitive small-molecule inhibitor of multipletyrosine kinases (e. |
|
V0503
|
Apatinib (Rivoceranib, YN968D1) |
811803-05-1 |
Apatinib (formerly known as Rivoceranib,YN-968D1) is a potent, orally bioavailable, and selective inhibitor of the VEGF (vascular endothelial growth factor receptor) signaling pathway withpotential antiangiogenic and antineoplastic activities. |
|
V0522
|
Semaxanib (SU-5416) |
204005-46-9 |
Semaxanib (also known as SU5416) is a novel, potent and selective VEGFR (Flk-1/KDR) inhibitor with potential anticancer activity. |
|
V0300
|
Olaparib (AZD2281; KU0059436) |
763113-22-0 |
Olaparib (formerly also known as AZD-2281; KU-59436; KU0059436; trade name Lynparza) is a potent,novel and orally bioavailable small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential anticancer activity. |
|
V0174
|
Rapamycin (Sirolimus; AY22989) |
53123-88-9 |
Rapamycin (also known as Sirolimus; AY-22989), a natural macrocyclic lactone isolated from the bacterium Streptomyces hygroscopicus, is a specific and potent mTOR inhibitor with IC50 of ~0.1 nM in HEK293 cells. |
|
V0001
|
Venetoclax (ABT-199; GDC-0199) |
1257044-40-8 |
Venetoclax (formerly known as ABT-199 or GDC-0199; Venclexta) is a potent, selective andorally bioavailablesmall molecule inhibitor of theanti-apoptotic protein BCL-2 (B-cell lymphoma-2) with Ki of<0.01 nM. |
|
V0415
|
Apabetalone (RVX-08, RVX-000222) |
1044870-39-4 |
Apabetalone (also known as RVX-208, RVX000222) is a novel and potent inhibitor of BET (Bromodomain and Extra-Terminal) bromodomain (BD) with potential anti-inflammatory activity and the potential to be used in the treatment of cardiovascular diseases. |
|
V0729
|
Ritonavir (ABT-538; Norvir) |
155213-67-5 |
Ritonavir (previously known as ABT-538; A-84538; RTV; ABT538, trade name: Norvir) is a L-valine derivative and potent inhibitor of HIV-1 protease used to treat HIV infection and AIDS. It is widely used as a booster for other protease inhibitors/PIs such as lopinavir, and makes them work better. |
|
V0024
|
Belnacasan (VX765) |
273404-37-8 |
Belnacasan (also known as VX-765) is a novel, potent, selective and orally bioactive prodrug of VRT-043198 which is a potent and selective inhibitor of caspase-1 withKi values of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. |
|
V0411
|
(+)-JQ1 |
1268524-70-4 |
(+)-JQ1 is a novel, potent and highly specific BET (Bromodomain and extra terminal domain) bromodomain inhibitor with antineoplastic activity. |
|
V0390
|
EPZ015666 (GSK3235025) |
1616391-65-1 |
EPZ015666 (GSK-3235025), an analog ofEPZ-015866, is a potent, selective and orally bioavailable inhibitor of PRMT5 (protein arginine methyltransferase) with antineoplastic activity. |
|
V0075
|
AZD1390 |
2089288-03-7 |
AZD1390 (AZD-1390) is a novel, potent, selective, first-in-class orally bioavailable and CNS penetrant inhibitor ofAtaxia-telangiectasia mutated (ATM) kinase with potential anticancer activity. |