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    Estradiol valerate (β-estradiol 17-valerate)
    Estradiol valerate (β-estradiol 17-valerate)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1748
    CAS #: 979-32-8Purity ≥98%

    Description: Estradiol valerate (β-estradiol 17-valerate; Estraval; Progynova; Valergen; Altadiol; Deladiol; Delestrogen), the 17β-valerate ester of estradiol, is a synthetic, steroidal estrogen and an estrogen ester commonly used in combination with other steroid hormones in hormone replacement therapies. It acts as a prodrug of estradiol, and hence, is considered to be a natural, bioidentical form of estrogen. Along with estradiol cypionate, estradiol valerate is one of the most widely used esters of estradiol. Estradiol, or more precisely, the 17-beta-isomer of estradiol, is a human sex hormone and steroid, and the primary female sex hormone. 

    References: J Neurosci. 1997 Mar 1;17(5):1848-59; J Neurosci. 1992 Jul;12(7):2549-54.

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    Molecular Weight (MW)356.5 
    FormulaC23H32O3 
    CAS No.979-32-8 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 71 mg/mL (199.1 mM) 
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: (17β)-3-hydroxyestra-1,3,5(10)-trien-17-yl valerate

    InChi Key: RSEPBGGWRJCQGY-RBRWEJTLSA-N

    InChi Code: InChI=1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3/t18-,19-,20+,21+,23+/m1/s1

    SMILES Code: CCCCC(O[[email protected]]1CC[[email protected]@]2([H])[[email protected]]3([H])CCC4=C(C=CC(O)=C4)[[email protected]@]3([H])CC[[email protected]]12C)=O

    Synonyms

    Estraval; Progynova; Valergen; Altadiol; Deladiol; Delestrogen; oestradiol valerate;


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    In Vitro

    In vitro activity: Estradiol (10 nM) rapidly activates sphingosine kinase isoenzyme SphK1 as determined by enhanced phosphorylation on Ser225 in MCF-7 cells. Estradiol (20 nM) stimulates rapid release of sphingosine 1-phosphate (S1P) and dihydro-S1P from MCF-7 cells. SphK1 and estrogen receptor α are mainly responsible for formation of S1P and dihydro-S1P. Down-regulation of ABCC1 or ABCG2 with siRNAs or pharmacological inhibitors decreases Estradiol (10 nM)-mediated release of S1P or dihydro-S1P from MCF-7 cells. Estradiol (10 nM) inhibits miR-21 expression in MCF-7 human breast cancer cells mediated by estrogen receptor α. Estradiol (10 nM) activates several miR-21 target gene reporters activity in MCF-7 cells through inhibiting miR-21 expression. Estradiol (10 nM) increases endogenous miR-21 target genes expression in protein but not RNA levels in MCF-7 cells.

    In VivoEstradiol (80 μg/kg/day, s.c.) significantly decreases the absolute numbers of total peritoneal cell and macrophages, characterized by a double F4/80- and CD11b-positive staining, in ovariectomized C57BL/6J mice. Estradiol (80 μg/kg/day, s.c.) enhances the LPS-induced expression of proinflammatory cytokines by TGC-elicited macrophages through inhibition of PI3K activity in ovariectomized C57BL/6J mice. Proinflammatory effect of Estradiol is abolished by downregulate estrogen receptor α activity in thioglycolate-elicited macrophages. 
    Animal modelMice
    Formulation & Dosage80 μg/kg/day, s.c.
    References

    J Biol Chem. 2010 Apr 2;285(14):10477-86; Nucleic Acids Res. 2009 May;37(8):2584-95; J Immunol. 2010 Jul 15;185(2):1169-76. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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