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    Estradiol Cypionate (Depoestradiol)
    Estradiol Cypionate (Depoestradiol)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1750
    CAS #: 313-06-4Purity ≥98%

    Description: Estradiol cypionate (Depoestradiol; β-Estradiol 17-cypionate) is the 17 β-cyclopentylpropinate ester of estradiol used in hormone therapy for menopausal symptoms and low estrogen levels in women. It acts by inhibiting ET-1 synthesis via estrogen receptor. Estradiol cypionate is a synthetic ester of the natural estrogen, estradiol. Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate is found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate are found to last for 4-5 days and 7-8 days, respectively. 

    References: Contraception. 1980 Apr;21(4):415-24; J Am Vet Med Assoc. 2003 Sep 15;223(6):846-51.

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    Molecular Weight (MW)396.56 
    FormulaC26H36O3 
    CAS No.313-06-4 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 79 mg/mL (199.2 mM) 
    Water: <1 mg/mL
    Ethanol: 55 mg/mL (138.7 mM) 
    Other info

    Chemical Name: Cyclopentanepropionic acid, 3-hydroxyestra-1,3,5(10)-trien-17beta-yl ester

    InChi Key: UOACKFBJUYNSLK-XRKIENNPSA-N

    InChi Code: InChI=1S/C26H36O3/c1-26-15-14-21-20-10-8-19(27)16-18(20)7-9-22(21)23(26)11-12-24(26)29-25(28)13-6-17-4-2-3-5-17/h8,10,16-17,21-24,27H,2-7,9,11-15H2,1H3/t21-,22-,23+,24+,26+/m1/s1

    SMILES Code: O=C(O[[email protected]]1CC[[email protected]@]2([H])[[email protected]]3([H])CCC4=C(C=CC(O)=C4)[[email protected]@]3([H])CC[[email protected]]12C)CCC5CCCC5

    Synonyms

    Estradiol cypionate; β-Estradiol 17-cypionate


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    In Vitro

    In vitro activity: Estradiol cypionate is a synthetic ester of the natural estrogen, estradiol. Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate is found to have the longest duration of action with a duration of ~11 days, while estradiol benzoate and estradiol valerate are found to last for 4-5 days and 7-8 days, respectively. Estradiol cypionate has several indications for use in bovine medicine. These include treatment of anestrus in the absence of follicular cysts, persistent corpus luteum, pyometra, and retained placenta. Potentially, ECP may benefit high-risk postpartum cows by stimulating uterine contractions either directly or through maintenance of oxytocin receptor sites in the uterus, bringing more WBCs to the site of infection by increasing blood flow to the uterus, enhancing uterine immune function by increasing phagocytosis of bacteria or movement of IgA and IgG into the uterine lumen, or promoting uterine drainage by delaying closure of the cervix.

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    References

    Contraception. 1980 Apr;21(4):415-24; J Am Vet Med Assoc. 2003 Sep 15;223(6):846-51. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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