| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| Targets |
Buffer; pH adjuster
|
|---|---|
| ln Vitro |
After traumatic brain injury, hypertonic sodium lactate solution enhances cognitive function (TBI). In pig models of traumatic brain injury, hypertonic sodium lactate solution also lowers intracranial pressure (ICP) and raises cerebral blood flow via arteriolar vasodilation [2][3]. Pseudomonas, lactobacilli, Enterobacteriaceae, aerobic and psychrophilic flora, and other skewed human resources are inhibited by sodium lactate [6].
|
| ln Vivo |
Design and setting: Prospective open randomized study in an adult ICU.
Patients: Thirty-four patients with isolated severe TBI (Glasgow Coma Scale |
| Animal Protocol |
Measurements and results: Compared to mannitol, the effect of the lactate solution on ICP was significantly more pronounced (7 vs. 4 mmHg, P = 0.016), more prolonged (fourth-hour-ICP decrease: -5.9 +/- 1 vs. -3.2 +/- 0.9 mmHg, P = 0.009) and more frequently successful (90.4 vs. 70.4%, P = 0.053).
Conclusion: Acute infusion of a sodium lactate-based hyperosmolar solution is effective in treating intracranial hypertension following traumatic brain injury. This effect is significantly more pronounced than that of an equivalent osmotic load of mannitol. Additionally, in this specific group of patients, long-term outcome was better in terms of GOS in those receiving as compared to mannitol. Larger trials are warranted to confirm our findings.[2]
|
| Toxicity/Toxicokinetics |
The intraperitoneal LD50 in rats was 2 g/kg. (FAO Nutrition Conference Report Series, 40(144), 1967)
The intravenous LD50 in rats was >1 g/kg. Sensory organs and special senses: ptosis; Behavior: lethargy (reduced overall activity); Lungs, pleura, or respiration: dyspnea. (Kiso & Clinical), 21(3289), 1987 The intravenous LD50 in mice was 2190 mg/kg. (Japanese Medicine), -(938), 1995 |
| References | |
| Additional Infomation |
Sodium lactate is an organic sodium salt whose counterion is lactate. It can be used as a food preservative and a food acidity regulator. It is an organic sodium salt and also a lactate salt. It contains lactate. Sodium lactate is the sodium salt of racemic or inactive lactic acid, and has alkalizing and electrolyte-replenishing effects. After metabolism, sodium lactate is converted to bicarbonate, thereby increasing plasma bicarbonate concentration, promoting the clearance of hydrogen ions and lactate from the blood, and leading to an increase in blood pH. Compound sodium lactate solution is a multi-electrolyte isotonic crystalloid solution for intravenous infusion, containing sodium chloride, potassium chloride, calcium chloride dihydrate, and sodium lactate. It can restore electrolyte balance, regulate pH, and provide hydration to replenish body fluids. After intravenous infusion, compound sodium lactate solution can replenish lost body fluids and electrolytes, thereby replenishing hydration and normalizing electrolyte concentrations. Furthermore, the conversion of sodium lactate to bicarbonate increases plasma bicarbonate levels, thereby promoting the clearance of hydrogen ions from the blood, increasing blood pH, and restoring acid-base balance to normal. Sodium lactate is the sodium salt of racemic or inactive lactic acid. It is a hygroscopic drug that can be administered intravenously as a systemic and urinary alkalizing agent. See also: Sodium cation (with the active moiety)... See more...
|
| Molecular Formula |
C3H5NAO3
|
|---|---|
| Molecular Weight |
112.0598
|
| Exact Mass |
112.013
|
| CAS # |
72-17-3
|
| Related CAS # |
Lactate;50-21-5;Lactate calcium;814-80-2;Lactate-d4 sodium;344299-52-1;Lactate-d3 sodium;1219802-24-0;Lactate-13C sodium;81273-81-6;Lactate-13C-1 sodium;201595-70-2;Lactate potassium;996-31-6
|
| PubChem CID |
23666456
|
| Appearance |
Colorless to light yellow liquid
|
| Density |
1.33
|
| Boiling Point |
227.6ºC at 760 mmHg
|
| Melting Point |
17ºC
|
| Flash Point |
109.9ºC
|
| Index of Refraction |
1.422-1.425
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
3
|
| Rotatable Bond Count |
1
|
| Heavy Atom Count |
7
|
| Complexity |
63.2
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
[Na+].O([H])C([H])(C(=O)[O-])C([H])([H])[H]
|
| InChi Key |
NGSFWBMYFKHRBD-UHFFFAOYSA-M
|
| InChi Code |
InChI=1S/C3H6O3.Na/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);/q;+1/p-1
|
| Chemical Name |
sodium;2-hydroxypropanoate
|
| Synonyms |
compound sodium lactate solution; SODIUM LACTATE; 72-17-3; Sodium DL-lactate; Lactic acid sodium salt; Monosodium lactate; sodium 2-hydroxypropanoate; Lacolin;
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ≥ 150 mg/mL (~1338.57 mM)
DMSO : ≥ 100 mg/mL (~892.38 mM) |
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 8.9238 mL | 44.6190 mL | 89.2379 mL | |
| 5 mM | 1.7848 mL | 8.9238 mL | 17.8476 mL | |
| 10 mM | 0.8924 mL | 4.4619 mL | 8.9238 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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