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    Upadacitinib tartrate
    Upadacitinib tartrate

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4510
    CAS #: 1607431-21-9Purity ≥98%

    Description: Upadacitinib tartrate (formerly ABT494; ABT-494; rinvoq), the tartrate salt of Upadacitinib, is a novel, potent and selective Janus kinase (JAK) 1 inhibitor approved in 2019 for the treatment of rheumatoid arthritis. It inhibits JAK1 with an IC50 of 43 nM, and was developed for the treatment of several autoimmune disorders, e.g. rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling.

    ReferencesBioDrugs. 2016 Oct;30(5):407-419.

    Related  CAS: 1607431-21-9 (tartarte); 1310726-60-3 (free base)

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    Upadacitinib tartrate

    Name: Upadacitinib tartrate
    CAS#: 1607431-21-9 (tartarte)
    Chemical Formula: C21H25F3N6O7
    Molecular Weight: 530.4612
    Elemental Analysis: C, 47.55; H, 4.75; F, 10.74; N, 15.84; O, 21.11
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: ABT-494 tartrate; ABT 494 tartrate; ABT494; rinvoq
    Chemical Name: (3S,4R)-3-ethyl-4-(3H-imidazo(1,2-a)pyrrolo(2,3-e)pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide (2R,3R)-2,3-dihydroxybutanedioate
    InChi Key: WQDBPGWQDBPVQZ-NBCXFSEXSA-N
    InChi Code: InChI=1S/C17H19F3N6O.C4H6O6/c1-2-10-7-25(16(27)24-9-17(18,19)20)8-11(10)13-5-22-14-6-23-15-12(26(13)14)3-4-21-15;5-1(3(7)8)2(6)4(9)10/h3-6,10-11,21H,2,7-9H2,1H3,(H,24,27);1-2,5-6H,(H,7,8)(H,9,10)/t10-,11+;1-,2-/m11/s1
    SMILES Code: O=C(N1C[[email protected]@H](CC)[[email protected]@H](C2=CN=C3C=NC(NC=C4)=C4N32)C1)NCC(F)(F)F.O=C(O)[[email protected]](O)[[email protected]@H](O)C(O)=O


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