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    Upadacitinib
    Upadacitinib

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4509
    CAS #: 1310726-60-3 (free base)Purity ≥98%

    Description: Upadacitinib (also known as ABT-494) is a novel, potent and selective Janus kinase (JAK) 1 inhibitor with an IC50 of 43 nM, it is being developed for the treatment of several autoimmune disorders, e.g. rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling.

    References: BioDrugs. 2016 Oct;30(5):407-419.

    Related CAS : 1310726-60-3 (free base); 1607431-21-9 (tartarte)  

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    Upadacitinib

    Name: Upadacitinib
    CAS#: 1310726-60-3 (free base)
    Chemical Formula: C17H19F3N6O
    Exact Mass: 380.1572
    Molecular Weight: 380.3752
    Elemental Analysis: C, 53.68; H, 5.04; F, 14.98; N, 22.09; O, 4.21
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: ABT-494, ABT 494, ABT494
    IUPAC/Chemical Name: (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
    InChi Key: WYQFJHHDOKWSHR-MNOVXSKESA-N
    InChi Code: InChI=1S/C17H19F3N6O/c1-2-10-7-25(16(27)24-9-17(18,19)20)8-11(10)13-5-22-14-6-23-15-12(26(13)14)3-4-21-15/h3-6,10-11,21H,2,7-9H2,1H3,(H,24,27)/t10-,11+/m1/s1
    SMILES Code: O=C(N1C[[email protected]@H](CC)[[email protected]@H](C2=CN=C3C=NC(NC=C4)=C4N32)C1)NCC(F)(F)F


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