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Purity: ≥98%
TPT-260 (also known as TPU260 and R55) is a thiophene thiourea derivative with molecule weight 260.00 in free base form; There is no formal name yet, it is temporally called as TPT-260. TPT260 acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~ 5 µM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP. Similar products include: TPT-197; TPT-260; TPT-172 (R33; CAS#: 32415-42-2) etc.
References |
Nat Chem Biol.2014Jun;10(6):443-9.
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Molecular Formula |
C8H12N4S3
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Molecular Weight |
260.4027
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CAS # |
769856-81-7
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SMILES |
NC(SCC1=CC=C(CSC(N)=N)S1)=N.[H]Cl.[H]Cl
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InChi Key |
DSODRWWHAUGSGD-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C8H12N4S3.2ClH/c9-7(10)13-3-5-1-2-6(15-5)4-14-8(11)12;;/h1-2H,3-4H2,(H3,9,10)(H3,11,12);2*1H
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Chemical Name |
thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride
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Synonyms |
NSC-55712; NSC55712; NSC 55712; TPT260; TPT-260; TPT 260; TPT-260 HCl; TPT-260 2HCl; TPT-260 dihydrchloride; R55.
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.8402 mL | 19.2012 mL | 38.4025 mL | |
5 mM | 0.7680 mL | 3.8402 mL | 7.6805 mL | |
10 mM | 0.3840 mL | 1.9201 mL | 3.8402 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Identification of a retromer stabilizing pharmacological chaperone.Nat Chem Biol.2014Jun;10(6):443-9. th> |
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The pharmacological chaperone increases retromer levels in neurons.Nat Chem Biol.2014Jun;10(6):443-9. td> |
The pharmacological chaperone decreases Aβ peptide accumulation and reduces the pathogenic pathway of APP.Nat Chem Biol.2014Jun;10(6):443-9. td> |
The pharmacological chaperone shifts the endosomal localization of APP and SorL1.Nat Chem Biol.2014Jun;10(6):443-9. th> |
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The pharmacological chaperone specifically modulates Aβ production through the retromer pathway. Characterization of the weak link in retromer complex stability.Nat Chem Biol.2014Jun;10(6):443-9. td> |