| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
|
||
| 500mg | |||
| 1g | |||
| Other Sizes |
| Targets |
Ticarcillin sodium targets bacterial penicillin-binding proteins (PBPs) located in the bacterial cell wall. As a penicillin antibiotic, it inhibits the transpeptidase enzyme that cross-links peptidoglycan chains, a critical component of the bacterial cell wall. This disrupts cell wall synthesis, leading to bacterial cell lysis and death. It is effective against a broad spectrum of bacteria.
|
|---|---|
| ln Vitro |
In vitro, Ticarcillin sodium demonstrates broad-spectrum bactericidal activity against many Gram-positive and Gram-negative aerobic and anaerobic bacteria. It is particularly effective against Pseudomonas aeruginosa and is one of the few antibiotics capable of treating Stenotrophomonas maltophilia infections. Its activity is concentration-dependent.
|
| ln Vivo |
In vivo, Ticarcillin sodium is used as an injectable antibiotic for the treatment of serious infections caused by susceptible bacteria. It is indicated for the treatment of septicemia, peritonitis, bone and joint infections, postoperative infections, and skin and soft tissue infections. Its efficacy against Pseudomonas aeruginosa and Stenotrophomonas maltophilia makes it valuable for treating hospital-acquired infections.
|
| Enzyme Assay |
In vitro susceptibility testing for Ticarcillin sodium is performed using standardized methods such as broth microdilution or agar dilution. Various bacterial strains are cultured and exposed to serial dilutions of the compound. Minimum inhibitory concentrations (MIC) are determined as the lowest concentration that inhibits visible bacterial growth. The compound's activity is compared to other antibiotics.
|
| Cell Assay |
For in vitro cell-based assays, bacterial cultures are treated with Ticarcillin sodium at various concentrations. Bacterial growth is monitored by measuring optical density at 600 nm. Time-kill curves can be generated to assess the bactericidal activity. The compound's effects on bacterial cell morphology can be examined by electron microscopy. Cytotoxicity in mammalian cells can be assessed using MTT or standard assays.
|
| Animal Protocol |
In vivo animal studies with Ticarcillin sodium are conducted in models of bacterial infection. Animals are infected with pathogenic bacteria (e.g., Pseudomonas aeruginosa) and treated with the compound via intramuscular or intravenous injection. Efficacy is measured by survival rates, bacterial clearance from tissues, and resolution of infection symptoms. Pharmacokinetic studies assess the compound's distribution, metabolism, and excretion.
|
| ADME/Pharmacokinetics |
Ticarcillin sodium (CAS: 29457-07-6) has a molecular weight of 430.41 g/mol and a molecular formula of C15H16N2O6S2·2Na. Appearance: solid powder. Solubility: soluble in DMSO. Storage: room temperature. The compound is a semi-synthetic, broad-spectrum carboxypenicillin antibiotic.
|
| Toxicity/Toxicokinetics |
Ticarcillin sodium is an approved antibiotic with an established safety profile. Common side effects include allergic reactions (rash, urticaria), gastrointestinal disturbances, and injection site reactions. As with other penicillins, cross-hypersensitivity with other beta-lactam antibiotics may occur. It is contraindicated in patients with a history of hypersensitivity to penicillins.
|
| Additional Infomation |
Ticarcillin disodium is an organosodium salt containing the ticarcillin (2-) ion. Ticarcillin disodium is the disodium salt form of ticarcillin, a broad-spectrum semi-synthetic penicillin antibiotic with bactericidal and anti-β-lactamase activity. Its mechanism of action is similar to carbenicillin; ticarcillin inactivates the penicillin-sensitive C-terminal domain of transpeptidase by opening the lactam ring. This inactivation prevents the cross-linking of peptidoglycan chains, thereby inhibiting the third (and final) stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis, ultimately resulting in cell lysis. A penicillin antibiotic with a mechanism of action similar to carbenicillin. See also: potassium clavulanate; ticarcillin disodium (component).
Ticarcillin sodium is a semi-synthetic, broad-spectrum carboxypenicillin antibiotic with bactericidal activity against many Gram-positive and Gram-negative bacteria. It is particularly effective against Pseudomonas aeruginosa and is one of the few antibiotics capable of treating Stenotrophomonas maltophilia infections. It has a molecular weight of 430.41 g/mol and a molecular formula of C15H16N2O6S2·2Na. It is an approved antibiotic in many countries. |
| Molecular Formula |
C15H14N2O6S2-2.2[NA+]
|
|---|---|
| Molecular Weight |
428.39106
|
| Exact Mass |
428.009
|
| CAS # |
29457-07-6
|
| Related CAS # |
(2S,5R,6R)-Ticarcillin disodium;4697-14-7;Ticarcillin;34787-01-4
|
| PubChem CID |
470375
|
| Appearance |
White to off-white solid powder
|
| Boiling Point |
768.3ºC at 760 mmHg
|
| Flash Point |
418.4ºC
|
| Vapour Pressure |
7.97E-25mmHg at 25°C
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
8
|
| Rotatable Bond Count |
3
|
| Heavy Atom Count |
27
|
| Complexity |
629
|
| Defined Atom Stereocenter Count |
4
|
| SMILES |
O=C(N[C@H]1[C@H]2SC(C)(C)[C@H](C([O-])=O)N2C1=O)[C@H](C([O-])=O)C1C=CSC=1.[Na+].[Na+]
|
| InChi Key |
ZBBCUBMBMZNEME-QBGWIPKPSA-L
|
| InChi Code |
InChI=1S/C15H16N2O6S2.2Na/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6;;/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23);;/q;2*+1/p-2/t7-,8-,9+,12-;;/m1../s1
|
| Chemical Name |
disodium;(2S,5R,6R)-6-[[(2R)-2-carboxylato-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
|
|---|---|
| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3343 mL | 11.6716 mL | 23.3432 mL | |
| 5 mM | 0.4669 mL | 2.3343 mL | 4.6686 mL | |
| 10 mM | 0.2334 mL | 1.1672 mL | 2.3343 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
