| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
| Targets |
Ticarcillin sodium targets penicillin-binding proteins (PBPs) involved in bacterial cell wall synthesis. It functions by inhibiting bacterial cell wall biosynthesis at the level of peptidoglycan cross-linking, specifically by inhibiting peptidoglycan transpeptidases. This disrupts the integrity of the bacterial cell wall, leading to cell lysis and death. Its action is similar to that of carbenicillin.
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|---|---|
| ln Vitro |
Ticarcillin sodium has broad-spectrum bactericidal activity against many Gram-positive and Gram-negative aerobic and anaerobic bacteria. It is particularly effective against Gram-negative bacteria, especially Pseudomonas aeruginosa. It is a β-lactam antibiotic that prevents bacterial cell wall biosynthesis by inhibiting peptidoglycan transpeptidases. It is one of the few antibiotics effective against Stenotrophomonas maltophilia.
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| ln Vivo |
In vivo, Ticarcillin sodium is used to treat infections caused by susceptible bacteria, particularly those resistant to other antibiotics. It is commonly utilized in the treatment of serious infections, including septicemia, respiratory tract infections, urinary tract infections, and skin and soft tissue infections. It is often used in combination with beta-lactamase inhibitors to extend its spectrum.
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| Enzyme Assay |
In vitro assays for Ticarcillin sodium measure its antibacterial activity by determining the minimum inhibitory concentration (MIC) against various bacterial strains using broth microdilution or agar dilution methods. Its binding to penicillin-binding proteins can be studied using competitive binding assays with radiolabeled penicillin. Its inhibition of peptidoglycan transpeptidase can be measured using enzymatic assays.
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| Cell Assay |
In vitro cellular assays for Ticarcillin sodium involve treating bacterial cultures with the compound and measuring bacterial growth inhibition. The compound's effects on bacterial cell wall synthesis can be assessed by measuring the release of cell wall components or by electron microscopy. Its cytotoxicity against mammalian cells is also evaluated to assess its safety.
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| Animal Protocol |
In vivo animal models for Ticarcillin sodium include mouse or rat models of bacterial infection to evaluate its efficacy. Animals are infected with a pathogenic bacterium and then treated with the compound, and survival or bacterial load in organs is measured. These models help determine the compound's therapeutic potential and optimal dosing regimens.
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| ADME/Pharmacokinetics |
Ticarcillin sodium is administered intravenously or intramuscularly. It is not well-absorbed after oral administration. It is distributed widely in tissues and body fluids. It is excreted primarily in the urine as unchanged drug. Its half-life is approximately 1 hour, and dosing adjustments are required in patients with renal impairment.
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| Toxicity/Toxicokinetics |
Ticarcillin sodium is generally well-tolerated. Common side effects include gastrointestinal disturbances, hypersensitivity reactions (rash, urticaria), and local reactions at the injection site. As a penicillin, it may cause allergic reactions in patients with a history of penicillin allergy. Overdose may lead to neurotoxicity, especially in patients with renal impairment.
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| Additional Infomation |
Ticarcillin disodium is an organosodium salt containing the ticarcillin (2-) ion. Ticarcillin disodium is the disodium salt form of ticarcillin, a broad-spectrum semi-synthetic penicillin antibiotic with bactericidal and anti-β-lactamase activity. Its mechanism of action is similar to carbenicillin; ticarcillin inactivates the penicillin-sensitive C-terminal domain of transpeptidase by opening the lactam ring. This inactivation prevents the cross-linking of peptidoglycan chains, thereby inhibiting the third (and final) stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis, ultimately resulting in cell lysis. A penicillin antibiotic with a mechanism of action similar to carbenicillin. See also: potassium clavulanate; ticarcillin disodium (component).
Ticarcillin sodium is a broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal activity against Gram-negative and Gram-positive bacteria. It is a carboxypenicillin with beta-lactamase resistant activity. It is particularly effective against Pseudomonas aeruginosa and is used to treat serious infections. It inhibits bacterial cell wall synthesis by targeting penicillin-binding proteins. |
| Molecular Formula |
C15H14N2O6S2-2.2[NA+]
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|---|---|
| Molecular Weight |
428.39106
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| Exact Mass |
428.008
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| CAS # |
4697-14-7
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| Related CAS # |
Ticarcillin sodium;29457-07-6;Ticarcillin;34787-01-4
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| PubChem CID |
470375
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| Appearance |
White to off-white solid powder
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| Boiling Point |
768.3ºC at 760 mmHg
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| Flash Point |
418.4ºC
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
3
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| Heavy Atom Count |
27
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| Complexity |
629
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| Defined Atom Stereocenter Count |
4
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| SMILES |
O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C(C([O-])=O)C3=CSC=C3)=O)N1C2=O)[O-].[Na+].[Na+]
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| InChi Key |
ZBBCUBMBMZNEME-QBGWIPKPSA-L
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| InChi Code |
InChI=1S/C15H16N2O6S2.2Na/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6;;/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23);;/q;2*+1/p-2/t7-,8-,9+,12-;;/m1../s1
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| Chemical Name |
disodium;(2S,5R,6R)-6-[[(2R)-2-carboxylato-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~291.79 mM)
H2O : ≥ 100 mg/mL (~233.43 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (4.86 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (4.86 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.08 mg/mL (4.86 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 100 mg/mL (233.43 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3343 mL | 11.6716 mL | 23.3432 mL | |
| 5 mM | 0.4669 mL | 2.3343 mL | 4.6686 mL | |
| 10 mM | 0.2334 mL | 1.1672 mL | 2.3343 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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