Tianeptine sodium

Alias: Tianeptine; brand names: Tatinol; Tianeurax; Salymbra; Stablon; Coaxil
Cat No.:V0967 Purity: ≥98%
Tianeptine sodium (Stablon, Coaxil, Tianeurax, Tatinol,Salymbra), the sodium salt of tianeptine and an atypical antidepressant, is a potent and selective serotonin reuptake enhancer (SSRE) used primarily for the treatment of major depressive disorders.
Tianeptine sodium Chemical Structure CAS No.: 30123-17-2
Product category: 5-HT Receptor
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
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100mg
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Other Forms of Tianeptine sodium:

  • Tianeptine (Stablon, Coaxil)
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Tianeptine sodium (Stablon, Coaxil, Tianeurax, Tatinol, Salymbra), the sodium salt of tianeptine and an atypical antidepressant, is a potent and selective serotonin reuptake enhancer (SSRE) used primarily for the treatment of major depressive disorders. In addition, it can be used to treat other symptoms like irritable bowel syndrome or asthma. Although tianeptine is chemically a tricyclic antidepressant (TCA), its pharmacological characteristics differ from those of typical TCAs due to recent research suggesting that tianeptine affects neural plasticity by indirectly altering glutamate receptor activity (i.e., AMPA and NMDA receptors) and releasing BDNF.

Biological Activity I Assay Protocols (From Reference)
ln Vitro

In vitro activity: Tianeptine treatment lowers corticotropin-releasing factor (CRF) mRNA levels in dBNST in rats that are not stressed and stops the CMS-induced increase in these levels in the dBNST. In the ventral BNST and CeA of both CMS-exposed rats and non-stressed controls, tianeptine treatment dramatically reduces the levels of CRF mRNA. In anesthetized rats, tianeptine inhibits the stress-induced suppression of PB potentiation in CA1, but not the stress-induced enhancement of LTP in the basolateral nucleus (BLA) of the amygdala. When tianeptine is given to rats under anesthesia, it increases LTP in the amygdala and PB potentiation in the hippocampus under non-stressful circumstances. In rats, tianeptine reduces the behavioral symptoms of illness caused by peripheral LPS or IL-1beta, but not central LPS or IL-1beta. Tianeptine stops stress-induced attenuation of NMDA-EPSCs deactivation in rats and causes a normalized scaling of the amplitude ratio of NMDA receptor to AMPA/kainate receptor-mediated currents. Treatment with tianeptine dramatically lowers apoptosis in the dentate gyrus and temporal cortex in both stressed and control animals, but has no effect in the Ammons Horn. The nucleus accumbens is the only area in which tianeptine (2.5 mg/kg, intravenously) increases extracellular dopamine. In the striatum and nucleus accumbens, tianeptine dramatically increases the extracellular concentrations of homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC).

ln Vivo

Animal Protocol


References

[1]. Neuropharmacology . 2006 Jun;50(7):824-33.

[2]. Stress . 2006 Mar;9(1):29-40.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C21H24CLN2NAO4S
Molecular Weight
458.93
Exact Mass
436.12
Elemental Analysis
C, 54.96; H, 5.27; Cl, 7.72; N, 6.10; Na, 5.01; O, 13.94; S, 6.99
CAS #
30123-17-2
Appearance
Solid powder
SMILES
CN1C2=CC=CC=C2C(C3=C(S1(=O)=O)C=C(C=C3)Cl)NCCCCCCC(=O)[O-].[Na+]
InChi Key
ZLBSUOGMZDXYKE-UHFFFAOYSA-M
InChi Code
InChI=1S/C21H25ClN2O4S.Na/c1-24-18-9-6-5-8-16(18)21(23-13-7-3-2-4-10-20(25)26)17-12-11-15(22)14-19(17)29(24,27)28;/h5-6,8-9,11-12,14,21,23H,2-4,7,10,13H2,1H3,(H,25,26);/q;+1/p-1
Chemical Name
sodium;7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoate
Synonyms
Tianeptine; brand names: Tatinol; Tianeurax; Salymbra; Stablon; Coaxil
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: ~91 mg/mL (~198.3 mM)
Water: ~91 mg/mL (~198.3 mM)
Ethanol: ~91 mg/mL (~198.3 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.1790 mL 10.8949 mL 21.7898 mL
5 mM 0.4358 mL 2.1790 mL 4.3580 mL
10 mM 0.2179 mL 1.0895 mL 2.1790 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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Clinical Trial Information
NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04249596 Recruiting Drug: Tianeptine Sodium Treatment Resistant Depression New York State Psychiatric
Institute
October 14, 2020 Phase 4
Biological Data
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