Tetracaine HCl

Alias: Amethocalne HCl; Tetracaine hydrochloride; Amethocaine hydrochloride; Butylocaine; Curtacain; Decicain; Gingicain; PantocaineM; Intercaine; Leocaine; Menonasal; Niphanoid; Tetracaine HCl.
Cat No.:V1247 Purity: ≥98%
Tetracaine HCl (also called Amethocalne; Butylocaine; Curtacain; Decicain; Gingicain; PantocaineM; Intercaine; Leocaine; Menonasal; Niphanoid), thehydrochloride salt form of tetracaine, is a local anaesthetic and a channel function allosteric inhibitor.
Tetracaine HCl Chemical Structure CAS No.: 136-47-0
Product category: Dopamine Receptor
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
500mg
1g
2g
5g
10g
Other Sizes

Other Forms of Tetracaine HCl:

  • Tetracaine
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Tetracaine HCl (also called Amethocalne; Butylocaine; Curtacain; Decicain; Gingicain; PantocaineM; Intercaine; Leocaine; Menonasal; Niphanoid), the hydrochloride salt form of tetracaine, is a local anaesthetic and a channel function allosteric inhibitor. Tetracaine is used as a local anesthetic to numb the throat, nose, or eyes. It can also be applied topically to reduce pain before beginning an intravenous. Tetracaine works by preventing the sarcoplasmic reticulum's voltage-sensitive Ca2+ release. Additionally, tetracaine inhibits both Na+ CP types IV α and X α.

Biological Activity I Assay Protocols (From Reference)
Targets
Calcium channel
ln Vitro
Tetracaine hydrochloride (Amethocaine hydrochloride) is applied to modify the activity of ryanodine receptors, or calcium release channels, which regulate the release of calcium from intracellular reserves. Tetracaine hydrochloride inhibits channel function allosterically. Tetracaine inhibits spontaneous calcium release events initially at low concentrations and completely blocks release at high concentrations[1][2].
References
[1]. http://en.wikipedia.org/wiki/Tetracaine
[2]. http://www.ncbi.nlm.nih.gov/pubmed/9147318
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C15H25CLN2O2
Molecular Weight
300.82
Exact Mass
300.16
Elemental Analysis
C, 59.89; H, 8.38; Cl, 11.78; N, 9.31; O, 10.64
CAS #
136-47-0
Appearance
Solid powder
SMILES
CCCCNC1=CC=C(C=C1)C(=O)OCCN(C)C.Cl
InChi Key
PPWHTZKZQNXVAE-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H
Chemical Name
2-(dimethylamino)ethyl 4-(butylamino)benzoate;hydrochloride
Synonyms
Amethocalne HCl; Tetracaine hydrochloride; Amethocaine hydrochloride; Butylocaine; Curtacain; Decicain; Gingicain; PantocaineM; Intercaine; Leocaine; Menonasal; Niphanoid; Tetracaine HCl.
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: ~60 mg/mL (199.5 mM)
Water: ~60 mg/mL (~199.5 mM)
Ethanol: ~30 mg/mL (~99.7 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 3.3242 mL 16.6212 mL 33.2425 mL
5 mM 0.6648 mL 3.3242 mL 6.6485 mL
10 mM 0.3324 mL 1.6621 mL 3.3242 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

Molarity Calculator allows you to calculate the mass, volume, and/or concentration required for a solution, as detailed below:

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An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?
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  • Enter 10 in the Concentration box and choose the correct unit (mM)
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  • The answer of 17.513 mg appears in the Mass box. In a similar way, you may calculate the volume and concentration.

Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:
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  • The answer of 62.5 μL (0.1 ml) appears in the Volume (Start) box
g/mol

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
  • Molecular mass (or molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
  • Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
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In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

Clinical Trial Information
NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02863679 Completed Drug: Tetracaine hydrochloride
gel
Hysteroscopy Wenzhou Medical University May 2016 Not Applicable
NCT01304316 Completed Drug: Tetracaine HCl 3% and
Oxymetazoline HCl 0.05%
Anesthesia St. Renatus, LLC September 2010 Phase 2
NCT01710787 Completed Drug: Tetracaine HCl 3%
Drug: Placebo
Anesthesia St. Renatus, LLC October 2012 Phase 3
NCT01807624 Completed Drug: Tetracaine HCl 3% and
Oxymetazoline HCl 0.05%
Anesthesia St. Renatus, LLC March 2013 Phase 2
NCT01952990 Completed Drug: Tetracaine HCl 3% and
Oxymetazoline HCl 0.05%
Anesthesia St. Renatus, LLC September 2013 Phase 2
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