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    InvivoChem Cat #: V0867
    CAS #: 108605-62-5Purity ≥98%

    Description: Teriflunomide (formerly HMR-1726; HMR1726; A771726; A-771726; trade name Aubagio), the active metabolite of the immunomodulator drug-leflunomide, is an orally bioavailable immunomodulatory agent with potential suppressing effects against immune systems. It acts by blocking the enzyme dihydroorotate dehydrogenase, thus inhibiting pyrimidine de novo synthesis. Teriflunomide has been approved for the treatment of arthritis and multiple sclerosis (MS). Teriflunomide inhibits rapidly dividing cells, including activated T cells, which are thought to drive the disease process in MS.

    References: Ther Clin Risk Manag. 2013;9:177-90.

    Related CAS #: 163451-81-8

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    Molecular Weight (MW)270.21
    CAS No.108605-62-5
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 32 mg/mL (118.4 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info
    Chemical Name: (Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide.
    InChi Code: InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-
    SMILES Code: C/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O 
    SynonymsA77 1726, HMR-1726; A77 1726; Aubagio; A771726; A-771726; HMR1726; HMR 1726; teriflunomide; trade name: Aubagio.

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    In Vitro

    In vitro activity: Teriflunomide primarily acts as an inhibitor of dihydroorotate dehydrogenase (DHODH), a key mitochondrial enzyme involved in the de novo synthesis of pyrimidines in rapidly proliferating cells. By reducing the activity of high-avidity proliferating T lymphocytes and B lymphocytes, teriflunomide likely attenuates the inflammatory response to autoantigens in MS. Thus, teriflunomide can be considered a cytostatic rather than a cytotoxic drug to leukocytes.

    In VivoTeriflunomide has demonstrated beneficial effects in two independent animal models of demyelinating disease. In the dark agouti rat model of experimental autoimmune encephalitis (EAE), teriflunomide administration results in clinical, histopathological, and electrophysiological evidence of efficacy both as a prophylactic and therapeutic agent. Similarly, in the female Lewis rat model of EAE, teriflunomide administration results in beneficial prophylactic and therapeutic clinical effects, with a delay in disease onset and symptom severity. 
    Animal model Rats
    Formulation & Dosage N/A
    ReferencesTher Clin Risk Manag. 2013;9:177-90. 

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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