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Purity: ≥98%
Tebanicline tosylate (also known as ABT-594 tosylate, Ebanicline tosylate and ABT594 tosylate) is a novel, potent, orally bioavailable nAChR modulator with effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM. Tebanicline is a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott as a less toxic analogue of the potent poison dart frog-derived compound epibatidine, which is some 200x stronger than morphine as an analgesic but produces extremely dangerous toxic side effects. Like epibatidine, tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound. It acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes.
| Molecular Formula |
C9H11N2OCL.C7H8O3S
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|---|---|
| Molecular Weight |
370.85106
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| CAS # |
198283-74-8
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| Related CAS # |
203564-54-9 (HCl);209326-19-2 (2HCl);198283-73-7;198283-74-8; 209326-18-1 (benzoate);
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| SMILES |
ClC1=NC=C(OC[C@@H]2NCC2)C=C1.O=S(C3=CC=C(C)C=C3)(O)=O
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| InChi Key |
JCPWIGCGJUGLJQ-OGFXRTJISA-N
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| InChi Code |
InChI=1S/C9H11ClN2O.C7H8O3S/c10-9-2-1-8(5-12-9)13-6-7-3-4-11-7;1-6-2-4-7(5-3-6)11(8,9)10/h1-2,5,7,11H,3-4,6H2;2-5H,1H3,(H,8,9,10)/t7-;/m1./s1
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| Chemical Name |
Pyridine, 5-((2R)-2-azetidinylmethoxy)-2-chloro-, mono(4-methylbenzenesulfonate)
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| Synonyms |
ABT-594 tosylate; ABT 594; ABT594; Ebanicline tosylate.
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6965 mL | 13.4825 mL | 26.9651 mL | |
| 5 mM | 0.5393 mL | 2.6965 mL | 5.3930 mL | |
| 10 mM | 0.2697 mL | 1.3483 mL | 2.6965 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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