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    Tebanicline tosylate
    Tebanicline tosylate

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4416
    CAS #: 198283-74-8 (tosylate)Purity ≥98%

    Description: Tebanicline tosylate (also known as ABT-594 tosylate, Ebanicline tosylate and ABT594 tosylate) is a novel, potent, orally bioavailable nAChR modulator with effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM. Tebanicline is a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott as a less toxic analogue of the potent poison dart frog-derived compound epibatidine, which is some 200x stronger than morphine as an analgesic but produces extremely dangerous toxic side effects. Like epibatidine, tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound. It acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes.

    References: J Physiol Paris. 1998 Jun-Aug;92(3-4):221-4.Eur J Pharmacol. 1998 Apr 3;346(1):23-33.

    Related CAS: 203564-54-9 (HCl); 198283-73-7 (free base); 209326-19-2 (2HCl); 209326-18-1 (benzoate)  

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    Tebanicline tosylate

    Name: Tebanicline tosylate
    CAS#: 198283-74-8 (tosylate)
    Chemical Formula: C16H19ClN2O4S
    Exact Mass: 370.0754
    Molecular Weight: 370.848
    Elemental Analysis: C, 51.82; H, 5.16; Cl, 9.56; N, 7.55; O, 17.26; S, 8.65
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: ABT-594 tosylate; ABT 594; ABT594; Ebanicline tosylate.
    Chemical Name: Pyridine, 5-((2R)-2-azetidinylmethoxy)-2-chloro-, mono(4-methylbenzenesulfonate)
    InChi Key: JCPWIGCGJUGLJQ-OGFXRTJISA-N
    InChi Code: InChI=1S/C9H11ClN2O.C7H8O3S/c10-9-2-1-8(5-12-9)13-6-7-3-4-11-7;1-6-2-4-7(5-3-6)11(8,9)10/h1-2,5,7,11H,3-4,6H2;2-5H,1H3,(H,8,9,10)/t7-;/m1./s1
    SMILES Code: ClC1=NC=C(OC[[email protected]@H]2NCC2)C=C1.O=S(C3=CC=C(C)C=C3)(O)=O


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