My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    Tebanicline hydrochloride
    Tebanicline hydrochloride

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V4415
    CAS #: 203564-54-9 (HCl)Purity ≥98%

    Description: Tebanicline hydrochloride (also known as ABT-594, Ebanicline and ABT594 hydrochloride) is a novel, potent, orally bioavailable nAChR modulator with effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM. Tebanicline is a potent synthetic nicotinic (non-opioid) analgesic drug developed by Abbott as a less toxic analogue of the potent poison dart frog-derived compound epibatidine, which is some 200x stronger than morphine as an analgesic but produces extremely dangerous toxic side effects. Like epibatidine, tebanicline showed potent analgesic activity against neuropathic pain in both animal and human trials, but with far less toxicity than its parent compound. It acts as a partial agonist at neuronal nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes.

    References: J Physiol Paris. 1998 Jun-Aug;92(3-4):221-4.Eur J Pharmacol. 1998 Apr 3;346(1):23-33.

    Related CAS: 198283-73-7 (free base); 209326-19-2 (2HCl); 198283-74-8 (tosylate); 209326-18-1 (benzoate)  

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Related Products
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
     

    Tebanicline hydrochloride

    Name: Tebanicline HCl
    CAS#: 203564-54-9 (HCl)
    Chemical Formula: C9H12Cl2N2O
    Exact Mass: 198.056
    Molecular Weight: 235.108
    Elemental Analysis: C, 45.98; H, 5.14; Cl, 30.16; N, 11.92; O, 6.80
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: ABT-594 HCl; ABT 594; ABT594; Ebanicline.
    IUPAC/Chemical Name: 5-[[(2R)-azetidin-2-yl]methoxy]-2-chloropyridine hydrochloride
    InChi Key: GYVARJONEFSAJB-OGFXRTJISA-N
    InChi Code: InChI=1S/C9H11ClN2O.ClH/c10-9-2-1-8(5-12-9)13-6-7-3-4-11-7;/h1-2,5,7,11H,3-4,6H2;1H/t7-;/m1./s1
    SMILES Code: ClC1=NC=C(OC[[email protected]@H]2NCC2)C=C1.[H]Cl


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2

    These protocols are for reference only. InvivoChem does not independently validate these methods.

    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      prompt
      Do you confirm the receipt?