Size | Price | Stock | Qty |
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2mg |
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5mg |
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10mg |
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25mg |
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50mg |
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Other Sizes |
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Purity: ≥98%
SUVN-911 is a novel, potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. SUVN-911 has antidepressant activity.
ln Vitro |
SUVN-911 is more α4β2 selective than α3β4 nAChR[1]. SUVN-911 demonstrates strong selectivity for over 70 receptors, encompassing GPCRs, ion channels, hormones, peptides, enzymes, growth factors, and prostaglandins [1].
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ln Vivo |
Cardiovascular and gastrointestinal side effects are absent from SUVN-911 [1]. Significant antidepressant effects are demonstrated by SUVN-911 (1.0–10.0 mg/kg; oral; daily; for 3 days) [1]. Rats with SUVN-911 show signs of metabolic stability [1]. In Wistar rats, SUVN-911 (3 mg/kg; oral) showed a high oral exposure, a longer half-life, and sufficient brain penetration [1].
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Animal Protocol |
Animal/Disease Models: Male Wistar rat (180-230 g) [1]
Doses: 1 mg/kg, 3 mg/kg, 10.0 mg/kg Route of Administration: Orally, one time/day for 3 days Experimental Results: Shown Antidepressant-like activity, no evidence of tachyphylaxis. Animal/Disease Models: Male Wistar rat (225±25g) [1] Doses: 3mg/kg (pharmacokinetic/PK/PK analysis) Route of Administration: Oral. Experimental Results: AUC=3507ng*h/mL, T1/2=3.34 hrs (hrs (hours)). |
References |
[1]. Ramakrishna Nirogi, et al. Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression. J Med Chem. 2020 Mar 26;63(6):2833-2853.
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Molecular Formula |
C11H14CL2N2O
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Molecular Weight |
261.1477
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CAS # |
2414674-71-6
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SMILES |
ClC1C([H])=C([H])C(=C([H])N=1)OC([H])([H])[C@]1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@@]2([H])N1[H].Cl[H]
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~125 mg/mL (~478.65 mM)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.8292 mL | 19.1461 mL | 38.2922 mL | |
5 mM | 0.7658 mL | 3.8292 mL | 7.6584 mL | |
10 mM | 0.3829 mL | 1.9146 mL | 3.8292 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.