SUVN-911

Cat No.:V2189 Purity: ≥98%
SUVN-911 is a novel, potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM.
SUVN-911 Chemical Structure CAS No.: 2414674-71-6
Product category: nAChR
This product is for research use only, not for human use. We do not sell to patients.
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Other Forms of SUVN-911:

  • SUVN-911 free base
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

SUVN-911 is a novel, potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. SUVN-911 has antidepressant activity.

Biological Activity I Assay Protocols (From Reference)
ln Vitro
SUVN-911 is more α4β2 selective than α3β4 nAChR[1]. SUVN-911 demonstrates strong selectivity for over 70 receptors, encompassing GPCRs, ion channels, hormones, peptides, enzymes, growth factors, and prostaglandins [1].
ln Vivo
Cardiovascular and gastrointestinal side effects are absent from SUVN-911 [1]. Significant antidepressant effects are demonstrated by SUVN-911 (1.0–10.0 mg/kg; oral; daily; for 3 days) [1]. Rats with SUVN-911 show signs of metabolic stability [1]. In Wistar rats, SUVN-911 (3 mg/kg; oral) showed a high oral exposure, a longer half-life, and sufficient brain penetration [1].
Animal Protocol
Animal/Disease Models: Male Wistar rat (180-230 g) [1]
Doses: 1 mg/kg, 3 mg/kg, 10.0 mg/kg
Route of Administration: Orally, one time/day for 3 days
Experimental Results: Shown Antidepressant-like activity, no evidence of tachyphylaxis.

Animal/Disease Models: Male Wistar rat (225±25g) [1]
Doses: 3mg/kg (pharmacokinetic/PK/PK analysis)
Route of Administration: Oral.
Experimental Results: AUC=3507ng*h/mL, T1/2=3.34 hrs (hrs (hours)).
References
[1]. Ramakrishna Nirogi, et al. Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression. J Med Chem. 2020 Mar 26;63(6):2833-2853.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C11H14CL2N2O
Molecular Weight
261.1477
CAS #
2414674-71-6
SMILES
ClC1C([H])=C([H])C(=C([H])N=1)OC([H])([H])[C@]1([H])C([H])([H])[C@@]2([H])C([H])([H])[C@@]2([H])N1[H].Cl[H]
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO : ~125 mg/mL (~478.65 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 3.8292 mL 19.1461 mL 38.2922 mL
5 mM 0.7658 mL 3.8292 mL 7.6584 mL
10 mM 0.3829 mL 1.9146 mL 3.8292 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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