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    RGD (Arg-Gly-Asp)
    RGD (Arg-Gly-Asp)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1597
    CAS #: 99896-85-2Purity ≥98%

    Description: RGD (Arg-Gly-Asp) Peptides is a tripeptide and cell adhesion motif which can mimic cell adhesion proteins and bind to integrins. RGD peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Previous study demonstrates that RGD peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing.

    References: Annu Rev Cell Dev Biol. 1996;12:697-715; Nature. 1999 Feb 11;397(6719):534-9.

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    Molecular Weight (MW)346.34
    FormulaC12H22N6O6
    CAS No.99896-85-2
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: <1 mg/mL
    Water: 12 mg/mL (34.6 mM)
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: Arginylglycylaspartic acid

    InChi Key: IYMAXBFPHPZYIK-BQBZGAKWSA-N

    InChi Code: InChI=1S/C12H22N6O6/c13-6(2-1-3-16-12(14)15)10(22)17-5-8(19)18-7(11(23)24)4-9(20)21/h6-7H,1-5,13H2,(H,17,22)(H,18,19)(H,20,21)(H,23,24)(H4,14,15,16)/t6-,7-/m0/s1

    SMILES Code: O=C(O)C[[email protected]@H](C(O)=O)NC(CNC([[email protected]](CCCNC(N)=N)N)=O)=O           

    Synonyms

    RGD; Arg-Gly-Asp; Arg Gly Asp


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    In Vitro

    In vitro activity: The RGD sequence is the cell attachment site of a large number of adhesive extracellular matrix, blood, and cell surface proteins, and nearly half of the over 20 known integrins recognize this sequence in their adhesion protein ligands. The RGD peptides and mimics can be used to probe integrin functions in various biological systems. Drug design based on the RGD structure may provide new treatments for diseases such as thrombosis, osteoporosis, and cancer. RGD peptide acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Research demonstrates that RGD peptides promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. The RGD peptide can serve as a cell adhesion site of extracellular matrix, cell surface proteins, and integrins. In addition, RGD peptide can inhibit ACK-2 activation through cell adhesion.


    Cell Assay: RGD peptide can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Previous study demonstrates that RGD peptides promote apoptosis through activation of conformation changes enhancing pro-caspase-3 activation and autoprocessing.

    In VivoAnima study suggested that the RGD-4C-FITC-peptide bound to both endothelial and tumor cells in vivo and that peptide targeting should allow the delivery of therapeutic drugs to both endothelial and tumor cells.
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    References

    Annu Rev Cell Dev Biol. 1996;12:697-715; Nature. 1999 Feb 11;397(6719):534-9.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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